Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia
In this report, we describe a patient with a delayed cutaneous hypersensitivity reaction to evolocumab, a human monoclonal antibody directed against the serine protease proprotein convertase subtilisin/kexin type 9 used to reduce low-density lipoprotein concentrations in the treatment of familial hy...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-02-01
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| Series: | Alergologia Polska |
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| Online Access: | https://www.termedia.pl/Evolocumab-induced-delayed-skin-hypersensitivity-reaction-in-a-patient-with-familial-hypercholesterolaemia,123,52431,1,1.html |
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| _version_ | 1832584892522692608 |
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| author | Grzegorz Porebski Alicja Dziadowiec |
| author_facet | Grzegorz Porebski Alicja Dziadowiec |
| author_sort | Grzegorz Porebski |
| collection | DOAJ |
| description | In this report, we describe a patient with a delayed cutaneous hypersensitivity reaction to evolocumab, a human monoclonal antibody directed against the serine protease proprotein convertase subtilisin/kexin type 9 used to reduce low-density lipoprotein concentrations in the treatment of familial hypercholesterolaemia. The patient developed erythematous exfoliative lesions on the skin after the third administration of evolocumab. After each of the next three consecutive doses, the lesions worsened for 24 h, persisted for approximately 7 days, and then went into partial remission. Discontinuation of evolocumab resulted in a complete remission. Hypersensitivity reactions induced by biological drugs are becoming an increasing problem, but knowledge of these reactions is still limited. Our case report convincingly demonstrates the causal relationship between repeated drug exposure and the development and exacerbation of clinical symptoms. It also highlights a dilemma in the management of such clinical situations: the ‘treat-through’ strategy versus withdrawal of vital treatment. |
| format | Article |
| id | doaj-art-d664a7d649204accbc490229441c0416 |
| institution | Kabale University |
| issn | 2353-3854 2391-6052 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Alergologia Polska |
| spelling | doaj-art-d664a7d649204accbc490229441c04162025-01-27T10:33:52ZengTermedia Publishing HouseAlergologia Polska2353-38542391-60522024-02-01111737510.5114/pja.2024.13554652431Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemiaGrzegorz PorebskiAlicja DziadowiecIn this report, we describe a patient with a delayed cutaneous hypersensitivity reaction to evolocumab, a human monoclonal antibody directed against the serine protease proprotein convertase subtilisin/kexin type 9 used to reduce low-density lipoprotein concentrations in the treatment of familial hypercholesterolaemia. The patient developed erythematous exfoliative lesions on the skin after the third administration of evolocumab. After each of the next three consecutive doses, the lesions worsened for 24 h, persisted for approximately 7 days, and then went into partial remission. Discontinuation of evolocumab resulted in a complete remission. Hypersensitivity reactions induced by biological drugs are becoming an increasing problem, but knowledge of these reactions is still limited. Our case report convincingly demonstrates the causal relationship between repeated drug exposure and the development and exacerbation of clinical symptoms. It also highlights a dilemma in the management of such clinical situations: the ‘treat-through’ strategy versus withdrawal of vital treatment.https://www.termedia.pl/Evolocumab-induced-delayed-skin-hypersensitivity-reaction-in-a-patient-with-familial-hypercholesterolaemia,123,52431,1,1.htmlallergy familial hypercholesterolaemia drug hypersensitivity reactions evolocumab rash |
| spellingShingle | Grzegorz Porebski Alicja Dziadowiec Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia Alergologia Polska allergy familial hypercholesterolaemia drug hypersensitivity reactions evolocumab rash |
| title | Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia |
| title_full | Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia |
| title_fullStr | Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia |
| title_full_unstemmed | Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia |
| title_short | Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia |
| title_sort | evolocumab induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia |
| topic | allergy familial hypercholesterolaemia drug hypersensitivity reactions evolocumab rash |
| url | https://www.termedia.pl/Evolocumab-induced-delayed-skin-hypersensitivity-reaction-in-a-patient-with-familial-hypercholesterolaemia,123,52431,1,1.html |
| work_keys_str_mv | AT grzegorzporebski evolocumabinduceddelayedskinhypersensitivityreactioninapatientwithfamilialhypercholesterolaemia AT alicjadziadowiec evolocumabinduceddelayedskinhypersensitivityreactioninapatientwithfamilialhypercholesterolaemia |