Preclinical Toxicological Characterization of Porphyrin-Doped Conjugated Polymer Nanoparticles for Photodynamic Therapy

Preclinical Toxicological Characterization of Porphyrin-Doped Conjugated Polymer Nanoparticles for Photodynamic Therapy

<b>Background:</b> Photodynamic therapy (PDT) utilizing nano-based photosensitizers (PSs) offers promising cancer treatment potential but requires rigorous safety evaluation. Conjugated polymer nanoparticles (CPNs) doped with porphyrins, such as platinum porphyrin–doped poly(9,9-dioctylf...

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Main Authors: Matías Daniel Caverzan, Ana Belén Morales Vasconsuelo, Laura Cerchia, Rodrigo Emiliano Palacios, Carlos Alberto Chesta, Luis Exequiel Ibarra
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
conjugated polymer nanoparticles
biocompatibility
toxicity evaluation
single and repeated dose toxicity
photodynamic therapy
Online Access:https://www.mdpi.com/1999-4923/17/5/593
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