The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies
Mushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood. AHCC® is a standardized extract of cultured shiitake or Lentinula...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/3758576 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566857677144064 |
|---|---|
| author | Min Sun Shin Hong-Jai Park Takahiro Maeda Hiroshi Nishioka Hajime Fujii Insoo Kang |
| author_facet | Min Sun Shin Hong-Jai Park Takahiro Maeda Hiroshi Nishioka Hajime Fujii Insoo Kang |
| author_sort | Min Sun Shin |
| collection | DOAJ |
| description | Mushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood. AHCC® is a standardized extract of cultured shiitake or Lentinula edodes mycelia (ECLM) which contains a mixture of nutrients including oligosaccharides, amino acids, and minerals obtained through liquid culture. AHCC® is reported to modulate the numbers and functions of immune cells including natural killer (NK) and T cells which play important roles in host defense, suggesting the possible implication of its supplementation in defending the host against infections and malignancies via modulating the immune system. Here, we review in vivo and in vitro effects of AHCC® on NK and T cells of humans and animals in health and disease, providing a platform for the better understanding of immune-mediated mechanisms and clinical implications of AHCC®. |
| format | Article |
| id | doaj-art-d64d8066780d430e8ea7f74c76a68a5e |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d64d8066780d430e8ea7f74c76a68a5e2025-02-03T01:03:05ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/37585763758576The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal StudiesMin Sun Shin0Hong-Jai Park1Takahiro Maeda2Hiroshi Nishioka3Hajime Fujii4Insoo Kang5Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USAResearch and Development Division, Amino Up Co., Ltd., 004-0839 Sapporo, JapanResearch and Development Division, Amino Up Co., Ltd., 004-0839 Sapporo, JapanResearch and Development Division, Amino Up Co., Ltd., 004-0839 Sapporo, JapanDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USAMushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood. AHCC® is a standardized extract of cultured shiitake or Lentinula edodes mycelia (ECLM) which contains a mixture of nutrients including oligosaccharides, amino acids, and minerals obtained through liquid culture. AHCC® is reported to modulate the numbers and functions of immune cells including natural killer (NK) and T cells which play important roles in host defense, suggesting the possible implication of its supplementation in defending the host against infections and malignancies via modulating the immune system. Here, we review in vivo and in vitro effects of AHCC® on NK and T cells of humans and animals in health and disease, providing a platform for the better understanding of immune-mediated mechanisms and clinical implications of AHCC®.http://dx.doi.org/10.1155/2019/3758576 |
| spellingShingle | Min Sun Shin Hong-Jai Park Takahiro Maeda Hiroshi Nishioka Hajime Fujii Insoo Kang The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies Journal of Immunology Research |
| title | The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies |
| title_full | The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies |
| title_fullStr | The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies |
| title_full_unstemmed | The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies |
| title_short | The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies |
| title_sort | effects of ahcc r a standardized extract of cultured lentinura edodes mycelia on natural killer and t cells in health and disease reviews on human and animal studies |
| url | http://dx.doi.org/10.1155/2019/3758576 |
| work_keys_str_mv | AT minsunshin theeffectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT hongjaipark theeffectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT takahiromaeda theeffectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT hiroshinishioka theeffectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT hajimefujii theeffectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT insookang theeffectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT minsunshin effectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT hongjaipark effectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT takahiromaeda effectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT hiroshinishioka effectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT hajimefujii effectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies AT insookang effectsofahccastandardizedextractofculturedlentinuraedodesmyceliaonnaturalkillerandtcellsinhealthanddiseasereviewsonhumanandanimalstudies |