A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogen and host cells must survive. Currently, whether hypoxia adaptation is an important virulence attribut...

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Bibliographic Details
Main Authors: Sven D Willger, Srisombat Puttikamonkul, Kwang-Hyung Kim, James B Burritt, Nora Grahl, Laurel J Metzler, Robert Barbuch, Martin Bard, Christopher B Lawrence, Robert A Cramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000200&type=printable
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