Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19
Coronavirus disease 2019 (COVID-19) has been raised as a pandemic disease since December 2019. Immunosuppressive cells including T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are key players in immunological tolerance and immunoregulation; however, they contribute to the pa...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5545319 |
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| author | Alhasan Alsalman Mohammad A. Al-Mterin Eyad Elkord |
| author_facet | Alhasan Alsalman Mohammad A. Al-Mterin Eyad Elkord |
| author_sort | Alhasan Alsalman |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) has been raised as a pandemic disease since December 2019. Immunosuppressive cells including T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are key players in immunological tolerance and immunoregulation; however, they contribute to the pathogenesis of different diseases including infections. Tregs have been shown to impair the protective role of CD8+ T lymphocytes against viral infections. In COVID-19 patients, most studies reported reduction, while few other studies found elevation in Treg levels. Moreover, Tregs have a dual role, depending on the different stages of COVID-19 disease. At early stages of COVID-19, Tregs have a critical role in decreasing antiviral immune responses, and consequently reducing the viral clearance. On the other side, during late stages, Tregs reduce inflammation-induced organ damage. Therefore, inhibition of Tregs in early stages and their expansion in late stages have potentials to improve clinical outcomes. In viral infections, MDSC levels are highly increased, and they have the potential to suppress T cell proliferation and reduce viral clearance. Some subsets of MDSCs are expanded in the blood of COVID-19 patients; however, there is a controversy whether this expansion has pathogenic or protective effects in COVID-19 patients. In conclusion, further studies are required to investigate the role and function of immunosuppressive cells and their potentials as prognostic biomarkers and therapeutic targets in COVID-19 patients. |
| format | Article |
| id | doaj-art-d647111efb5d4e80a527304a4c9cd0f1 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d647111efb5d4e80a527304a4c9cd0f12025-02-03T01:22:45ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5545319Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19Alhasan Alsalman0Mohammad A. Al-Mterin1Eyad Elkord2Natural and Medical Sciences Research CenterNatural and Medical Sciences Research CenterNatural and Medical Sciences Research CenterCoronavirus disease 2019 (COVID-19) has been raised as a pandemic disease since December 2019. Immunosuppressive cells including T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are key players in immunological tolerance and immunoregulation; however, they contribute to the pathogenesis of different diseases including infections. Tregs have been shown to impair the protective role of CD8+ T lymphocytes against viral infections. In COVID-19 patients, most studies reported reduction, while few other studies found elevation in Treg levels. Moreover, Tregs have a dual role, depending on the different stages of COVID-19 disease. At early stages of COVID-19, Tregs have a critical role in decreasing antiviral immune responses, and consequently reducing the viral clearance. On the other side, during late stages, Tregs reduce inflammation-induced organ damage. Therefore, inhibition of Tregs in early stages and their expansion in late stages have potentials to improve clinical outcomes. In viral infections, MDSC levels are highly increased, and they have the potential to suppress T cell proliferation and reduce viral clearance. Some subsets of MDSCs are expanded in the blood of COVID-19 patients; however, there is a controversy whether this expansion has pathogenic or protective effects in COVID-19 patients. In conclusion, further studies are required to investigate the role and function of immunosuppressive cells and their potentials as prognostic biomarkers and therapeutic targets in COVID-19 patients.http://dx.doi.org/10.1155/2022/5545319 |
| spellingShingle | Alhasan Alsalman Mohammad A. Al-Mterin Eyad Elkord Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 Journal of Immunology Research |
| title | Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 |
| title_full | Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 |
| title_fullStr | Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 |
| title_full_unstemmed | Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 |
| title_short | Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 |
| title_sort | role of t regulatory cells and myeloid derived suppressor cells in covid 19 |
| url | http://dx.doi.org/10.1155/2022/5545319 |
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