Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study
BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells....
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1473905/full |
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| author | Wenjing Cao Zefu Yang Liumei Mo Zhenhao Liu Jiawei Wang Zhenhong Zhang Kui Wang Wei Pan |
| author_facet | Wenjing Cao Zefu Yang Liumei Mo Zhenhao Liu Jiawei Wang Zhenhong Zhang Kui Wang Wei Pan |
| author_sort | Wenjing Cao |
| collection | DOAJ |
| description | BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. The objective of the current research was to explore the potential connections between immune characteristics and the development of HF, as well as to ascertain the nature of the causality between these factors.MethodsTo assess the causal association of immunological profiles with HF based on publicly available genome-wide studies, we employed a two-sample Mendelian randomization technique, utilizing the inverse variance weighted (IVW) method as our primary analytical approach. In addition, we assessed heterogeneity and cross-sectional pleiotropy through sensitivity analyses.ResultsA two-sample Mendelian randomization (MR) analysis was conducted using IVW as the primary method. At a significance level of 0.001, we identified 40 immunophenotypes that have a significant causal relationship with HF. There is a significant causal relationship between these phenotypes and heart failure. These immunophenotypes, 8 of which were in B cells, 5 in cDC, 2 in T cell maturation stage, 2 in monocytes, 3 in myeloid cells, 7 in TBNK and 13 in Treg. Sensitivity analyses were conducted to validate the strength and reliability of the MR findings.ConclusionsOur study suggests that there appears to be a causal effect between multiple immune cells on heart failure. This discovery provides a new avenue for the development of therapeutic treatments for HF and a new target for drug development. |
| format | Article |
| id | doaj-art-d63ddfc6327440cb9d7d776b9cc88258 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-d63ddfc6327440cb9d7d776b9cc882582025-01-23T06:56:22ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14739051473905Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization studyWenjing Cao0Zefu Yang1Liumei Mo2Zhenhao Liu3Jiawei Wang4Zhenhong Zhang5Kui Wang6Wei Pan7Department of Cardiology, Department of Geriatric Medicine, Foshan Women and Children's Hospital, Foshan, Guangdong, ChinaDepartment of Cardiology, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, Guangdong, ChinaDepartment of Cardiology, Department of Geriatric Medicine, Foshan Women and Children's Hospital, Foshan, Guangdong, ChinaDepartment of Cardiovascular Medicine, Pingxiang People's Hospital, Jiangxi, ChinaDepartment of Critical Care Medicine, Jieyang Third People's Hospital, Jieyang, Guangdong, ChinaDepartment of Cardiology Medical, The Second People's Hospital of Foshan, Foshan, ChinaThe First Clinical Medical College, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Cardiology, Department of Geriatric Medicine, Foshan Women and Children's Hospital, Foshan, Guangdong, ChinaBackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. The objective of the current research was to explore the potential connections between immune characteristics and the development of HF, as well as to ascertain the nature of the causality between these factors.MethodsTo assess the causal association of immunological profiles with HF based on publicly available genome-wide studies, we employed a two-sample Mendelian randomization technique, utilizing the inverse variance weighted (IVW) method as our primary analytical approach. In addition, we assessed heterogeneity and cross-sectional pleiotropy through sensitivity analyses.ResultsA two-sample Mendelian randomization (MR) analysis was conducted using IVW as the primary method. At a significance level of 0.001, we identified 40 immunophenotypes that have a significant causal relationship with HF. There is a significant causal relationship between these phenotypes and heart failure. These immunophenotypes, 8 of which were in B cells, 5 in cDC, 2 in T cell maturation stage, 2 in monocytes, 3 in myeloid cells, 7 in TBNK and 13 in Treg. Sensitivity analyses were conducted to validate the strength and reliability of the MR findings.ConclusionsOur study suggests that there appears to be a causal effect between multiple immune cells on heart failure. This discovery provides a new avenue for the development of therapeutic treatments for HF and a new target for drug development.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1473905/fullcausal inferenceMR analysisimmunityheart failuregenome-wide association study |
| spellingShingle | Wenjing Cao Zefu Yang Liumei Mo Zhenhao Liu Jiawei Wang Zhenhong Zhang Kui Wang Wei Pan Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study Frontiers in Cardiovascular Medicine causal inference MR analysis immunity heart failure genome-wide association study |
| title | Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study |
| title_full | Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study |
| title_fullStr | Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study |
| title_full_unstemmed | Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study |
| title_short | Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study |
| title_sort | causal relationship between immune cells and risk of heart failure evidence from a mendelian randomization study |
| topic | causal inference MR analysis immunity heart failure genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1473905/full |
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