Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia
Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail to adequately address the complexity of...
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MDPI AG
2025-01-01
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| author | Vijay Murali Ravi Mythili Ramya Lakshmi Rajendran Raksa Arun Vasanth Kanth Thasma Loganathbabu Danyal Reyaz ArulJothi Kandasamy Nagarajan Byeong-Cheol Ahn Prakash Gangadaran |
| author_facet | Vijay Murali Ravi Mythili Ramya Lakshmi Rajendran Raksa Arun Vasanth Kanth Thasma Loganathbabu Danyal Reyaz ArulJothi Kandasamy Nagarajan Byeong-Cheol Ahn Prakash Gangadaran |
| author_sort | Vijay Murali Ravi Mythili |
| collection | DOAJ |
| description | Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail to adequately address the complexity of CLI, necessitating the identification of alternative methodologies. This review explores uncharted territory beyond traditional therapies, focusing on the potential of two distinct yet interrelated entities: cell-derived extracellular vesicles (EVs) and artificial nanovesicles. Cell-derived EVs are small membranous structures naturally released by cells, and artificial nanovesicles are artificially engineered nanosized vesicles. Both these vesicles represent promising avenues for therapeutic intervention. They act as carriers of bioactive cargo, including proteins, nucleic acids, and lipids, that can modulate intricate cellular responses associated with ischemic tissue repair and angiogenesis. This review also assesses the evolving landscape of CLI revascularization through the unique perspective of cell-derived EVs and artificial nanovesicles. The review spans the spectrum from early preclinical investigations to the latest translational advancements, providing a comprehensive overview of the current state of research in this emerging field. These groundbreaking vesicle therapies hold immense potential for revolutionizing CLI treatment paradigms. |
| format | Article |
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| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Bioengineering |
| spelling | doaj-art-d62fa48367aa47ae98bd6eb0292921b92025-01-24T13:23:15ZengMDPI AGBioengineering2306-53542025-01-011219210.3390/bioengineering12010092Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb IschemiaVijay Murali Ravi Mythili0Ramya Lakshmi Rajendran1Raksa Arun2Vasanth Kanth Thasma Loganathbabu3Danyal Reyaz4ArulJothi Kandasamy Nagarajan5Byeong-Cheol Ahn6Prakash Gangadaran7Integrative Genetics and Molecular Oncology Group, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chengalpattu 603203, Tamil Nadu, IndiaDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaIntegrative Genetics and Molecular Oncology Group, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chengalpattu 603203, Tamil Nadu, IndiaIntegrative Genetics and Molecular Oncology Group, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chengalpattu 603203, Tamil Nadu, IndiaIntegrative Genetics and Molecular Oncology Group, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chengalpattu 603203, Tamil Nadu, IndiaIntegrative Genetics and Molecular Oncology Group, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chengalpattu 603203, Tamil Nadu, IndiaDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of KoreaCritical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail to adequately address the complexity of CLI, necessitating the identification of alternative methodologies. This review explores uncharted territory beyond traditional therapies, focusing on the potential of two distinct yet interrelated entities: cell-derived extracellular vesicles (EVs) and artificial nanovesicles. Cell-derived EVs are small membranous structures naturally released by cells, and artificial nanovesicles are artificially engineered nanosized vesicles. Both these vesicles represent promising avenues for therapeutic intervention. They act as carriers of bioactive cargo, including proteins, nucleic acids, and lipids, that can modulate intricate cellular responses associated with ischemic tissue repair and angiogenesis. This review also assesses the evolving landscape of CLI revascularization through the unique perspective of cell-derived EVs and artificial nanovesicles. The review spans the spectrum from early preclinical investigations to the latest translational advancements, providing a comprehensive overview of the current state of research in this emerging field. These groundbreaking vesicle therapies hold immense potential for revolutionizing CLI treatment paradigms.https://www.mdpi.com/2306-5354/12/1/92critical limb ischemiaextracellular vesiclesnanovesiclesrevascularizationregenerative medicine |
| spellingShingle | Vijay Murali Ravi Mythili Ramya Lakshmi Rajendran Raksa Arun Vasanth Kanth Thasma Loganathbabu Danyal Reyaz ArulJothi Kandasamy Nagarajan Byeong-Cheol Ahn Prakash Gangadaran Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia Bioengineering critical limb ischemia extracellular vesicles nanovesicles revascularization regenerative medicine |
| title | Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia |
| title_full | Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia |
| title_fullStr | Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia |
| title_full_unstemmed | Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia |
| title_short | Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia |
| title_sort | emerging strategies for revascularization use of cell derived extracellular vesicles and artificial nanovesicles in critical limb ischemia |
| topic | critical limb ischemia extracellular vesicles nanovesicles revascularization regenerative medicine |
| url | https://www.mdpi.com/2306-5354/12/1/92 |
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