Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine?
It was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1998/213028 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551493940543488 |
|---|---|
| author | Edemariam Tsega John Horton Erik Nordenfelt B-J Hansson Belachew Tafesse Gizachew Wolde-Hawariat Johan Lindberg |
| author_facet | Edemariam Tsega John Horton Erik Nordenfelt B-J Hansson Belachew Tafesse Gizachew Wolde-Hawariat Johan Lindberg |
| author_sort | Edemariam Tsega |
| collection | DOAJ |
| description | It was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10 and 20 µg hepatitis B vaccine doses, using the initial, one- and six-month schedule. Five years later, 210 of the vaccinees were retested for anti-HBV surface antibody titres. Both 10 and 20 µg doses of hepatitis B rDNA yeast vaccine were equally immunogenic and protective against HBV infection for at least five years despite marked reduction of mean antibody levels and geometric mean titres, with 11% of the vaccinees showing antibodies below the protective level. For firm further recommendations a longer follow-up period of vaccinees is suggested. |
| format | Article |
| id | doaj-art-d62c04c91bd841608fb888fb15991cac |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-d62c04c91bd841608fb888fb15991cac2025-02-03T06:01:19ZengWileyCanadian Journal of Gastroenterology0835-79001998-01-01121576010.1155/1998/213028Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine?Edemariam Tsega0John Horton1Erik Nordenfelt2B-J Hansson3Belachew Tafesse4Gizachew Wolde-Hawariat5Johan Lindberg6Department of Internal Medicine, Faculty of Medicine, Memorial University, St John’s, Newfoundland, CanadaDepartment of Internal Medicine, Faculty of Medicine, Memorial University, St John’s, Newfoundland, CanadaSection of Clinical Virology, Department of Medical Virology, University of Lund, Malmö General Hospital, Malmö, SwedenSection of Clinical Virology, Department of Medical Virology, University of Lund, Malmö General Hospital, Malmö, SwedenDepartment of Internal Medicine, Faculty of Medicine, Addis Ababa University, and Birla Clinic, Yekatit 12 Hospital, Addis Ababa, EthiopiaDepartment of Internal Medicine, Faculty of Medicine, Addis Ababa University, and Birla Clinic, Yekatit 12 Hospital, Addis Ababa, EthiopiaDepartment of Internal Medicine, Faculty of Medicine, Addis Ababa University, and Birla Clinic, Yekatit 12 Hospital, Addis Ababa, EthiopiaIt was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10 and 20 µg hepatitis B vaccine doses, using the initial, one- and six-month schedule. Five years later, 210 of the vaccinees were retested for anti-HBV surface antibody titres. Both 10 and 20 µg doses of hepatitis B rDNA yeast vaccine were equally immunogenic and protective against HBV infection for at least five years despite marked reduction of mean antibody levels and geometric mean titres, with 11% of the vaccinees showing antibodies below the protective level. For firm further recommendations a longer follow-up period of vaccinees is suggested.http://dx.doi.org/10.1155/1998/213028 |
| spellingShingle | Edemariam Tsega John Horton Erik Nordenfelt B-J Hansson Belachew Tafesse Gizachew Wolde-Hawariat Johan Lindberg Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine? Canadian Journal of Gastroenterology |
| title | Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine? |
| title_full | Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine? |
| title_fullStr | Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine? |
| title_full_unstemmed | Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine? |
| title_short | Antibody Levels in Ethiopian Children Five Years after Vaccination with Two Different Doses of Hepatitis B Vaccine: Is There a Need for Booster Vaccine? |
| title_sort | antibody levels in ethiopian children five years after vaccination with two different doses of hepatitis b vaccine is there a need for booster vaccine |
| url | http://dx.doi.org/10.1155/1998/213028 |
| work_keys_str_mv | AT edemariamtsega antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine AT johnhorton antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine AT eriknordenfelt antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine AT bjhansson antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine AT belachewtafesse antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine AT gizachewwoldehawariat antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine AT johanlindberg antibodylevelsinethiopianchildrenfiveyearsaftervaccinationwithtwodifferentdosesofhepatitisbvaccineisthereaneedforboostervaccine |