An exploratory analysis on diastolic function in the intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trialResearch in context

An exploratory analysis on diastolic function in the intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trialResearch in context

Summary: Background: Relationship between blood pressure (BP) control and left ventricular (LV) diastolic function in children with chronic kidney disease (CKD) is uncertain. The aim of this study is to investigate whether achieving lower BP yields a favourable impact on diastolic function. Methods...

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Main Authors: Haotian Gu, John M. Simpson, Janette Cansick, Eric Finlay, Rodney Gilbert, Andrew Lunn, Heather Maxwell, Henry Morgan, Mohan Shenoy, Rukshana Shroff, Pushpa Subramaniam, Jane Tizard, Yincent Tse, Phil Chowienczyk, Manish D. Sinha, Abdel Douiri, Larissa Kerecuk, Reza Razavi, Poothirikovil Venugopalan, John Simpson, Manish Sinha
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EBioMedicine
Subjects:
Diastolic function
Blood pressure
Hypertension
Children
Chronic kidney disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001355
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