The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus
Abstract Data on the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) and adiponectin in prediabetes progression to type 2 diabetes mellitus (T2DM) remains inconclusive. Therefore, this study investigated the roles of PCSK9 and adiponectin in this process. This study included 1,5...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-93750-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849772470120218624 |
|---|---|
| author | Jun-Xu Gu Kun Wang Ai-Min Zhang Yue Yin Shan-Shan Li Na Zhang Li Qin Chun-Yan Wang Lin Pei Mei Jia Ming Su |
| author_facet | Jun-Xu Gu Kun Wang Ai-Min Zhang Yue Yin Shan-Shan Li Na Zhang Li Qin Chun-Yan Wang Lin Pei Mei Jia Ming Su |
| author_sort | Jun-Xu Gu |
| collection | DOAJ |
| description | Abstract Data on the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) and adiponectin in prediabetes progression to type 2 diabetes mellitus (T2DM) remains inconclusive. Therefore, this study investigated the roles of PCSK9 and adiponectin in this process. This study included 1,528 participants with prediabetes and T2DM and conducted correlation analyses to investigate the relationship between PCSK9 and adiponectin levels, pancreatic beta-cell function, and insulin levels. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to determine whether PCSK9 and adiponectin play protective roles in the progression from prediabetes to T2DM and their potential as diagnostic biomarkers for T2DM. In prediabetic patients, the levels of PCSK9 [573.00 (412.35) ng/mL vs. 924.20 (673.38) ng/mL, p < 0.001] and adiponectin [4.50 (2.80) mg/mL vs. 6.22 (4.51) mg/mL, p < 0.001] were significantly higher than those in patients with T2DM. PCSK9 (r = 0.167, p < 0.001) and adiponectin (r = 0.113, p < 0.001) levels were positively correlated with pancreatic cell homeostasis and had protective effects against progression from prediabetes to T2DM (PCSK9: OR = 0.274, 95% CI 0.121–0.621, p = 0.002; adiponectin: OR = 0.135, 95% CI 0.057–0.320, p < 0.001). The combined diagnostic value of PCSK9 and adiponectin for T2DM showed an area under the curve of 0.751 (95% CI 0.727–0.775). Prediabetes and T2DM patients showed significant differences in the PCSK9 and adiponectin levels. PCSK9 and adiponectin have protective effects against the progression of prediabetes to T2DM, and their combined use is a potential biomarker for the transition from prediabetes to T2DM. |
| format | Article |
| id | doaj-art-d62447a2f79c42e493ebe9331289cdfd |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d62447a2f79c42e493ebe9331289cdfd2025-08-20T03:02:19ZengNature PortfolioScientific Reports2045-23222025-03-0115111210.1038/s41598-025-93750-7The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitusJun-Xu Gu0Kun Wang1Ai-Min Zhang2Yue Yin3Shan-Shan Li4Na Zhang5Li Qin6Chun-Yan Wang7Lin Pei8Mei Jia9Ming Su10Department of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Xiangya Hospital, Central South UniversityDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalDepartment of Clinical Laboratory, Peking University People’s HospitalAbstract Data on the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) and adiponectin in prediabetes progression to type 2 diabetes mellitus (T2DM) remains inconclusive. Therefore, this study investigated the roles of PCSK9 and adiponectin in this process. This study included 1,528 participants with prediabetes and T2DM and conducted correlation analyses to investigate the relationship between PCSK9 and adiponectin levels, pancreatic beta-cell function, and insulin levels. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to determine whether PCSK9 and adiponectin play protective roles in the progression from prediabetes to T2DM and their potential as diagnostic biomarkers for T2DM. In prediabetic patients, the levels of PCSK9 [573.00 (412.35) ng/mL vs. 924.20 (673.38) ng/mL, p < 0.001] and adiponectin [4.50 (2.80) mg/mL vs. 6.22 (4.51) mg/mL, p < 0.001] were significantly higher than those in patients with T2DM. PCSK9 (r = 0.167, p < 0.001) and adiponectin (r = 0.113, p < 0.001) levels were positively correlated with pancreatic cell homeostasis and had protective effects against progression from prediabetes to T2DM (PCSK9: OR = 0.274, 95% CI 0.121–0.621, p = 0.002; adiponectin: OR = 0.135, 95% CI 0.057–0.320, p < 0.001). The combined diagnostic value of PCSK9 and adiponectin for T2DM showed an area under the curve of 0.751 (95% CI 0.727–0.775). Prediabetes and T2DM patients showed significant differences in the PCSK9 and adiponectin levels. PCSK9 and adiponectin have protective effects against the progression of prediabetes to T2DM, and their combined use is a potential biomarker for the transition from prediabetes to T2DM.https://doi.org/10.1038/s41598-025-93750-7PCSK9AdiponectinT2DMPrediabetes |
| spellingShingle | Jun-Xu Gu Kun Wang Ai-Min Zhang Yue Yin Shan-Shan Li Na Zhang Li Qin Chun-Yan Wang Lin Pei Mei Jia Ming Su The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus Scientific Reports PCSK9 Adiponectin T2DM Prediabetes |
| title | The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus |
| title_full | The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus |
| title_fullStr | The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus |
| title_full_unstemmed | The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus |
| title_short | The correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus |
| title_sort | correlation between proprotein convertase subtilisin kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus |
| topic | PCSK9 Adiponectin T2DM Prediabetes |
| url | https://doi.org/10.1038/s41598-025-93750-7 |
| work_keys_str_mv | AT junxugu thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT kunwang thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT aiminzhang thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT yueyin thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT shanshanli thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT nazhang thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT liqin thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT chunyanwang thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT linpei thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT meijia thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT mingsu thecorrelationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT junxugu correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT kunwang correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT aiminzhang correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT yueyin correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT shanshanli correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT nazhang correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT liqin correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT chunyanwang correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT linpei correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT meijia correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus AT mingsu correlationbetweenproproteinconvertasesubtilisinkexintype9andadiponectinintheprogressionfromprediabetestotype2diabetesmellitus |