Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions
Aim. The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren’s syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonaut...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/2075803 |
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| author | Zygmunt Mackiewicz Justyna Mażul Ieva Narkevičiūtė Irena Dumalakienė Irena Butrimienė Rita Vilienė Indrė Stankevičienė Diana Mieliauskaitė |
| author_facet | Zygmunt Mackiewicz Justyna Mażul Ieva Narkevičiūtė Irena Dumalakienė Irena Butrimienė Rita Vilienė Indrė Stankevičienė Diana Mieliauskaitė |
| author_sort | Zygmunt Mackiewicz |
| collection | DOAJ |
| description | Aim. The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren’s syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonautoimmune sicca syndrome (nSS). Materials and Methods. 126 patients (119 women and 7 men) were grouped into four groups: (1) patients with primary Sjögren’s syndrome (pSS), (2) patients with secondary Sjögren’s syndrome due to rheumatoid arthritis (sSS), (3) patients with rheumatoid arthritis (RA), and (4) patients with nonautoimmune sicca syndrome (nSS). Immunohistochemical analysis of immune response to the suggested silent persistence of mumps virus in the minor labial salivary gland biopsies and flow cytometric analysis of blood cells was done. Results. Immunohistochemical signs of mumps virus persistence were found in the minor salivary glands of all study groups. Also, a significantly different immune response to virus infection (protein IFI16, interferons gamma and beta, dendritic cells, and receptor for natural killers) was revealed in the minor salivary glands of the study groups. Cytometric analysis of the blood cells revealed a dropping amount of circulating natural killers and dendritic cells in patients with SS. Significant correlations between immunohistochemical staining and serological findings were revealed. Conclusions. Abundant immunohistochemical signs of mumps virus protein in the salivary glands and depletion of circulating immune cells make a background for thought of presumable mumps or/and other virus participation in epithelial damage causing sicca syndrome in predisposed patients. |
| format | Article |
| id | doaj-art-d61f57659da848d383ec3ec8d880b7d5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d61f57659da848d383ec3ec8d880b7d52025-02-03T00:59:16ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/20758032075803Sjögren’s Syndrome: Concerted Triggering of Sicca ConditionsZygmunt Mackiewicz0Justyna Mażul1Ieva Narkevičiūtė2Irena Dumalakienė3Irena Butrimienė4Rita Vilienė5Indrė Stankevičienė6Diana Mieliauskaitė7Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaDepartment of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaDepartment of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaDepartment of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaDepartment of Experimental, Clinical and Preventive Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaDepartment of Immunology, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaVilnius University Hospital Žalgiris Clinics, LithuaniaDepartment of Experimental, Clinical and Preventive Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08406 Vilnius, LithuaniaAim. The aim of this study was to evaluate the expression of persistence of mumps virus and some cells that interact with viral infection in the focus of the autoimmune epithelitis and peripheral blood of Sjögren’s syndrome patients in comparison to patients with rheumatoid arthritis (RA) and nonautoimmune sicca syndrome (nSS). Materials and Methods. 126 patients (119 women and 7 men) were grouped into four groups: (1) patients with primary Sjögren’s syndrome (pSS), (2) patients with secondary Sjögren’s syndrome due to rheumatoid arthritis (sSS), (3) patients with rheumatoid arthritis (RA), and (4) patients with nonautoimmune sicca syndrome (nSS). Immunohistochemical analysis of immune response to the suggested silent persistence of mumps virus in the minor labial salivary gland biopsies and flow cytometric analysis of blood cells was done. Results. Immunohistochemical signs of mumps virus persistence were found in the minor salivary glands of all study groups. Also, a significantly different immune response to virus infection (protein IFI16, interferons gamma and beta, dendritic cells, and receptor for natural killers) was revealed in the minor salivary glands of the study groups. Cytometric analysis of the blood cells revealed a dropping amount of circulating natural killers and dendritic cells in patients with SS. Significant correlations between immunohistochemical staining and serological findings were revealed. Conclusions. Abundant immunohistochemical signs of mumps virus protein in the salivary glands and depletion of circulating immune cells make a background for thought of presumable mumps or/and other virus participation in epithelial damage causing sicca syndrome in predisposed patients.http://dx.doi.org/10.1155/2019/2075803 |
| spellingShingle | Zygmunt Mackiewicz Justyna Mażul Ieva Narkevičiūtė Irena Dumalakienė Irena Butrimienė Rita Vilienė Indrė Stankevičienė Diana Mieliauskaitė Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions Journal of Immunology Research |
| title | Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions |
| title_full | Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions |
| title_fullStr | Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions |
| title_full_unstemmed | Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions |
| title_short | Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions |
| title_sort | sjogren s syndrome concerted triggering of sicca conditions |
| url | http://dx.doi.org/10.1155/2019/2075803 |
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