A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets
This paper presents a RP-HPLC method for the simultaneous estimation of cefixime and cloxacillin in tablets. The process was carried out on C18 column (5 μm, 25 cm × 4.6 mm, i.d) using phosphate buffer (pH 5.0), acetonitrile and methanol in the ratio 80:17:3 respectively as a mobile phase at a flow...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/152390 |
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| author | G. Rathinavel P. B. Mukherjee J. Valarmathy L. Samueljoshua M. Ganesh T. Sivakumar T. Saravanan |
| author_facet | G. Rathinavel P. B. Mukherjee J. Valarmathy L. Samueljoshua M. Ganesh T. Sivakumar T. Saravanan |
| author_sort | G. Rathinavel |
| collection | DOAJ |
| description | This paper presents a RP-HPLC method for the simultaneous estimation of cefixime and cloxacillin in tablets. The process was carried out on C18 column (5 μm, 25 cm × 4.6 mm, i.d) using phosphate buffer (pH 5.0), acetonitrile and methanol in the ratio 80:17:3 respectively as a mobile phase at a flow rate of 2mL/min. Wavelength was fixed at 225 nm. The retention time of cefixime and cloxacillin was found to be 5.657 and 6.200 min, respectively. The developed method is rapid and sensitive and it can be used for estimation of combination of these drugs in tablets. |
| format | Article |
| id | doaj-art-d61be0dab9c140d09aa002fa99ea5980 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-d61be0dab9c140d09aa002fa99ea59802025-02-03T05:52:05ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015364865110.1155/2008/152390A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in TabletsG. Rathinavel0P. B. Mukherjee1J. Valarmathy2L. Samueljoshua3M. Ganesh4T. Sivakumar5T. Saravanan6Department of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, IndiaDepartment of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, IndiaDepartment of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, IndiaDepartment of Pharmaceutical Chemistry, Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu, IndiaDepartment of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, IndiaDepartment of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, IndiaDepartment of Pharmaceutical Chemistry, Nandha College of Pharmacy, Erode-638 052, Tamilnadu, IndiaThis paper presents a RP-HPLC method for the simultaneous estimation of cefixime and cloxacillin in tablets. The process was carried out on C18 column (5 μm, 25 cm × 4.6 mm, i.d) using phosphate buffer (pH 5.0), acetonitrile and methanol in the ratio 80:17:3 respectively as a mobile phase at a flow rate of 2mL/min. Wavelength was fixed at 225 nm. The retention time of cefixime and cloxacillin was found to be 5.657 and 6.200 min, respectively. The developed method is rapid and sensitive and it can be used for estimation of combination of these drugs in tablets.http://dx.doi.org/10.1155/2008/152390 |
| spellingShingle | G. Rathinavel P. B. Mukherjee J. Valarmathy L. Samueljoshua M. Ganesh T. Sivakumar T. Saravanan A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets E-Journal of Chemistry |
| title | A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets |
| title_full | A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets |
| title_fullStr | A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets |
| title_full_unstemmed | A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets |
| title_short | A Validated RP – HPLC Method for Simultaneous Estimation of Cefixime and Cloxacillin in Tablets |
| title_sort | validated rp hplc method for simultaneous estimation of cefixime and cloxacillin in tablets |
| url | http://dx.doi.org/10.1155/2008/152390 |
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