A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period

Here, we present the case of a 54-year-old female presenting for outpatient ankle hardware removal who experienced severe total body pruritus along with a maculopapular rash persisting four days after the procedure. Patch testing demonstrated a sensitivity to benzyl alcohol, a preservative in propof...

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Main Authors: Michael Tripp, Matthew Ribeiro, Susanna Kmiecik, Ramon Go
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Anesthesiology
Online Access:http://dx.doi.org/10.1155/2021/8859823
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author Michael Tripp
Matthew Ribeiro
Susanna Kmiecik
Ramon Go
author_facet Michael Tripp
Matthew Ribeiro
Susanna Kmiecik
Ramon Go
author_sort Michael Tripp
collection DOAJ
description Here, we present the case of a 54-year-old female presenting for outpatient ankle hardware removal who experienced severe total body pruritus along with a maculopapular rash persisting four days after the procedure. Patch testing demonstrated a sensitivity to benzyl alcohol, a preservative in propofol and several other anesthetics. The patient returned for left ankle arthroscopy a year later, and during that procedure, the anesthetic team avoided medications containing benzyl alcohol. This resulted in no pruritus or rash. Hypersensitivity reactions, ranging from contact dermatitis to anaphylaxis, are critical events in the perioperative period. Induction of general anesthesia has been implicated as the inciting event for perioperative hypersensitivity reactions. Benzyl alcohol is among a few excipients found in common anesthetic agents known to cause hypersensitivity reactions in susceptible patients. While reports of adult death are rare, infantile death due to benzyl alcohol has been described.
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spelling doaj-art-d60df345475745fd9ad1c3119ee5d6132025-02-03T05:43:47ZengWileyCase Reports in Anesthesiology2090-63822090-63902021-01-01202110.1155/2021/88598238859823A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative PeriodMichael Tripp0Matthew Ribeiro1Susanna Kmiecik2Ramon Go3Department of Anesthesiology, Medstar Georgetown University Medical Center, Washington, DC, USADepartment of Anesthesiology, Medstar Georgetown University Medical Center, Washington, DC, USADepartment of Anesthesiology, Medstar Georgetown University Medical Center, Washington, DC, USADepartment of Anesthesiology, Medstar Georgetown University Medical Center, Washington, DC, USAHere, we present the case of a 54-year-old female presenting for outpatient ankle hardware removal who experienced severe total body pruritus along with a maculopapular rash persisting four days after the procedure. Patch testing demonstrated a sensitivity to benzyl alcohol, a preservative in propofol and several other anesthetics. The patient returned for left ankle arthroscopy a year later, and during that procedure, the anesthetic team avoided medications containing benzyl alcohol. This resulted in no pruritus or rash. Hypersensitivity reactions, ranging from contact dermatitis to anaphylaxis, are critical events in the perioperative period. Induction of general anesthesia has been implicated as the inciting event for perioperative hypersensitivity reactions. Benzyl alcohol is among a few excipients found in common anesthetic agents known to cause hypersensitivity reactions in susceptible patients. While reports of adult death are rare, infantile death due to benzyl alcohol has been described.http://dx.doi.org/10.1155/2021/8859823
spellingShingle Michael Tripp
Matthew Ribeiro
Susanna Kmiecik
Ramon Go
A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period
Case Reports in Anesthesiology
title A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period
title_full A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period
title_fullStr A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period
title_full_unstemmed A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period
title_short A “Rash” Decision in Anesthetic Management: Benzyl Alcohol Allergy in the Perioperative Period
title_sort rash decision in anesthetic management benzyl alcohol allergy in the perioperative period
url http://dx.doi.org/10.1155/2021/8859823
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