Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential
Abstract The global increase in human life expectancy, coupled with an unprecedented rise in the prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart failure with preserved ejection fraction (HFpEF). Mechanistically, the molecular and cellular hallmarks of aging are...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-024-02566-8 |
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| author | Alexander Fuerlinger Alina Stockner Simon Sedej Mahmoud Abdellatif |
| author_facet | Alexander Fuerlinger Alina Stockner Simon Sedej Mahmoud Abdellatif |
| author_sort | Alexander Fuerlinger |
| collection | DOAJ |
| description | Abstract The global increase in human life expectancy, coupled with an unprecedented rise in the prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart failure with preserved ejection fraction (HFpEF). Mechanistically, the molecular and cellular hallmarks of aging are omnipresent in HFpEF and are further exacerbated by obesity and associated metabolic diseases. Conversely, weight loss strategies, particularly caloric restriction, have shown promise in improving health status in patients with HFpEF and are considered the gold standard for promoting longevity and healthspan (disease-free lifetime) in model organisms. In this review, we implicate fundamental mechanisms of aging in driving HFpEF and elucidate how caloric restriction mitigates the disease progression. Furthermore, we discuss the potential for pharmacologically mimicking the beneficial effects of caloric restriction in HFpEF using clinically approved and emerging caloric restriction mimetics. We surmise that these compounds could offer novel therapeutic avenues for HFpEF and alleviate the challenges associated with the implementation of caloric restriction and other lifestyle modifications to reduce the burden of HFpEF at a population level. |
| format | Article |
| id | doaj-art-d60bc8ee86ee4461b54b86f268f84d4f |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-d60bc8ee86ee4461b54b86f268f84d4f2025-01-19T12:09:04ZengBMCCardiovascular Diabetology1475-28402025-01-0124111710.1186/s12933-024-02566-8Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potentialAlexander Fuerlinger0Alina Stockner1Simon Sedej2Mahmoud Abdellatif3Department of Cardiology, Medical University of GrazDepartment of Cardiology, Medical University of GrazDepartment of Cardiology, Medical University of GrazDepartment of Cardiology, Medical University of GrazAbstract The global increase in human life expectancy, coupled with an unprecedented rise in the prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart failure with preserved ejection fraction (HFpEF). Mechanistically, the molecular and cellular hallmarks of aging are omnipresent in HFpEF and are further exacerbated by obesity and associated metabolic diseases. Conversely, weight loss strategies, particularly caloric restriction, have shown promise in improving health status in patients with HFpEF and are considered the gold standard for promoting longevity and healthspan (disease-free lifetime) in model organisms. In this review, we implicate fundamental mechanisms of aging in driving HFpEF and elucidate how caloric restriction mitigates the disease progression. Furthermore, we discuss the potential for pharmacologically mimicking the beneficial effects of caloric restriction in HFpEF using clinically approved and emerging caloric restriction mimetics. We surmise that these compounds could offer novel therapeutic avenues for HFpEF and alleviate the challenges associated with the implementation of caloric restriction and other lifestyle modifications to reduce the burden of HFpEF at a population level.https://doi.org/10.1186/s12933-024-02566-8AgingHFpEFObesityFastingCaloric restriction mimeticsSGLT2 |
| spellingShingle | Alexander Fuerlinger Alina Stockner Simon Sedej Mahmoud Abdellatif Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential Cardiovascular Diabetology Aging HFpEF Obesity Fasting Caloric restriction mimetics SGLT2 |
| title | Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential |
| title_full | Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential |
| title_fullStr | Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential |
| title_full_unstemmed | Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential |
| title_short | Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential |
| title_sort | caloric restriction and its mimetics in heart failure with preserved ejection fraction mechanisms and therapeutic potential |
| topic | Aging HFpEF Obesity Fasting Caloric restriction mimetics SGLT2 |
| url | https://doi.org/10.1186/s12933-024-02566-8 |
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