Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia
People affected with leukemia are on the rise and several strategies were employed to thwart this deadly disease. Recent decade of research focuses on phenolic constituents as a tool for combating various inflammatory, cancer, and cardiac diseases. Our research showed honey and its phenolic constitu...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/912051 |
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| author | Saravana Kumar Jaganathan Dilip Mondhe Z. A. Wani Eko Supriyanto |
| author_facet | Saravana Kumar Jaganathan Dilip Mondhe Z. A. Wani Eko Supriyanto |
| author_sort | Saravana Kumar Jaganathan |
| collection | DOAJ |
| description | People affected with leukemia are on the rise and several strategies were employed to thwart this deadly disease. Recent decade of research focuses on phenolic constituents as a tool for combating various inflammatory, cancer, and cardiac diseases. Our research showed honey and its phenolic constituents as crusaders against cancer. In this work, we explored the antileukemic activity of selected honey and one of its phenolic constituent eugenol against L1210 leukemia animal model. Results of this experiment showed that the selected honey samples as well as eugenol after intraperitoneal injection could not increase the median survival time (MST) of animals. Further, there was only slight marginal increase in the %T/C values of honey and eugenol treated groups. The number of phenolics present in the honey may not be a prime factor to promote antileukemic effect since there was no difference in the MST of two different honeys tested. This study limits the use of selected honey and eugenol against leukemia animal model. |
| format | Article |
| id | doaj-art-d60a0a9c9cf94716bec38668923b1266 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d60a0a9c9cf94716bec38668923b12662025-02-03T06:45:27ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/912051912051Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid LeukemiaSaravana Kumar Jaganathan0Dilip Mondhe1Z. A. Wani2Eko Supriyanto3IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaIndian Institute of Integrative Medicine, Jammu, Jammu and Kashmir 180 001, IndiaIndian Institute of Integrative Medicine, Jammu, Jammu and Kashmir 180 001, IndiaIJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaPeople affected with leukemia are on the rise and several strategies were employed to thwart this deadly disease. Recent decade of research focuses on phenolic constituents as a tool for combating various inflammatory, cancer, and cardiac diseases. Our research showed honey and its phenolic constituents as crusaders against cancer. In this work, we explored the antileukemic activity of selected honey and one of its phenolic constituent eugenol against L1210 leukemia animal model. Results of this experiment showed that the selected honey samples as well as eugenol after intraperitoneal injection could not increase the median survival time (MST) of animals. Further, there was only slight marginal increase in the %T/C values of honey and eugenol treated groups. The number of phenolics present in the honey may not be a prime factor to promote antileukemic effect since there was no difference in the MST of two different honeys tested. This study limits the use of selected honey and eugenol against leukemia animal model.http://dx.doi.org/10.1155/2014/912051 |
| spellingShingle | Saravana Kumar Jaganathan Dilip Mondhe Z. A. Wani Eko Supriyanto Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia The Scientific World Journal |
| title | Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia |
| title_full | Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia |
| title_fullStr | Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia |
| title_full_unstemmed | Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia |
| title_short | Evaluation of Selected Honey and One of Its Phenolic Constituent Eugenol against L1210 Lymphoid Leukemia |
| title_sort | evaluation of selected honey and one of its phenolic constituent eugenol against l1210 lymphoid leukemia |
| url | http://dx.doi.org/10.1155/2014/912051 |
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