The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients
Objective. To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients. Methods. The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness. We divided the patients into either the CAS group...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2013/835465 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555291106869248 |
|---|---|
| author | Hongqi Ren Xuan Zhou Zhiyong Luan Xiaomei Luo Shujing Han Qing Cai Wang Rui Yan Li |
| author_facet | Hongqi Ren Xuan Zhou Zhiyong Luan Xiaomei Luo Shujing Han Qing Cai Wang Rui Yan Li |
| author_sort | Hongqi Ren |
| collection | DOAJ |
| description | Objective. To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients. Methods. The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness. We divided the patients into either the CAS group or the non-CAS group based on the presence or absence of CAS. The parameters of ALB, Ca, P, TC, HDL, LDL, TG, glucose, creatinine, and hs-CRP levels were routinely tested in both groups of patients. The levels of TNF-α, IL-6, and 8-isoprostane F2α were measured by ELISA. Results. A total of 42 patients were enrolled in the CAS group and 20 patients were enrolled in the non-CAS group. No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb. However, SBP , pulse pressure, and 8-isoprostane levels of the CAS group were higher than those of the non-CAS group. The hs-CRP, TNF-α, and IL-6 levels were elevated in both groups but showed no significant differences. Conclusions. Maintenance of hemodialysis patients exhibits a microinflammatory state that may lead to atherosclerosis. The roles of hypertension and oxidative stress may be more important. |
| format | Article |
| id | doaj-art-d606203f070c4814a8716d824b84dde4 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-d606203f070c4814a8716d824b84dde42025-02-03T05:48:39ZengWileyInternational Journal of Nephrology2090-214X2090-21582013-01-01201310.1155/2013/835465835465The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis PatientsHongqi Ren0Xuan Zhou1Zhiyong Luan2Xiaomei Luo3Shujing Han4Qing Cai5Wang Rui6Yan Li7Department of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaDepartment of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaDepartment of Special Diagnosis, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaClinical Laboratory, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaDepartment of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaDepartment of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaDepartment of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaDepartment of Nephrology, Huaihai Hospital of Xuzhou Medical College, 226 Tongsan Road, Xuzhou 221004, ChinaObjective. To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients. Methods. The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness. We divided the patients into either the CAS group or the non-CAS group based on the presence or absence of CAS. The parameters of ALB, Ca, P, TC, HDL, LDL, TG, glucose, creatinine, and hs-CRP levels were routinely tested in both groups of patients. The levels of TNF-α, IL-6, and 8-isoprostane F2α were measured by ELISA. Results. A total of 42 patients were enrolled in the CAS group and 20 patients were enrolled in the non-CAS group. No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb. However, SBP , pulse pressure, and 8-isoprostane levels of the CAS group were higher than those of the non-CAS group. The hs-CRP, TNF-α, and IL-6 levels were elevated in both groups but showed no significant differences. Conclusions. Maintenance of hemodialysis patients exhibits a microinflammatory state that may lead to atherosclerosis. The roles of hypertension and oxidative stress may be more important.http://dx.doi.org/10.1155/2013/835465 |
| spellingShingle | Hongqi Ren Xuan Zhou Zhiyong Luan Xiaomei Luo Shujing Han Qing Cai Wang Rui Yan Li The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients International Journal of Nephrology |
| title | The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients |
| title_full | The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients |
| title_fullStr | The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients |
| title_full_unstemmed | The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients |
| title_short | The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients |
| title_sort | relationship between carotid atherosclerosis inflammatory cytokines and oxidative stress in middle aged and elderly hemodialysis patients |
| url | http://dx.doi.org/10.1155/2013/835465 |
| work_keys_str_mv | AT hongqiren therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT xuanzhou therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT zhiyongluan therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT xiaomeiluo therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT shujinghan therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT qingcai therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT wangrui therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT yanli therelationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT hongqiren relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT xuanzhou relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT zhiyongluan relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT xiaomeiluo relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT shujinghan relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT qingcai relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT wangrui relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients AT yanli relationshipbetweencarotidatherosclerosisinflammatorycytokinesandoxidativestressinmiddleagedandelderlyhemodialysispatients |