Hemophilia A Complicated by Ulcerative Colitis
Background. Hemophilia A is an X-linked recessive disorder characterized by defective synthesis of Factor VIII protein. Depending on the level of FVIII activity, patients may present with easy bruising, inadequate clotting of traumatic or mild injury, or in severe hemophilia, spontaneous hemorrhage....
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/2342618 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565611218075648 |
|---|---|
| author | Maxim Olivier Mario Madruga S. J. Carlan Li Ge |
| author_facet | Maxim Olivier Mario Madruga S. J. Carlan Li Ge |
| author_sort | Maxim Olivier |
| collection | DOAJ |
| description | Background. Hemophilia A is an X-linked recessive disorder characterized by defective synthesis of Factor VIII protein. Depending on the level of FVIII activity, patients may present with easy bruising, inadequate clotting of traumatic or mild injury, or in severe hemophilia, spontaneous hemorrhage. Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that is reported to have a decreased frequency of occurrence in subjects with coagulation disorders. Case. A 26-year-old white male with Hemophilia A was admitted for one month of rectal bleeding. The bleeding continued despite Factor VIII replacement and colonoscopy and biopsy were performed confirming the presence of active UC. Conclusion. Ulcerative colitis with underlying F VIII deficiency can result in serious, prolonged, and possibly fatal bleeding if left unrecognized and untreated. Treatment of both conditions concurrently utilizing tertiary facilities and consultations appears to be the safest strategy for management. |
| format | Article |
| id | doaj-art-d604a0cd48a549dabeadebc7803975ba |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-d604a0cd48a549dabeadebc7803975ba2025-02-03T01:07:10ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362018-01-01201810.1155/2018/23426182342618Hemophilia A Complicated by Ulcerative ColitisMaxim Olivier0Mario Madruga1S. J. Carlan2Li Ge3Department of Medicine, Orlando Regional Healthcare, Orlando, Florida, USADepartment of Medicine, Orlando Regional Healthcare, Orlando, Florida, USADivision of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, Florida, USADepartment of Pathology, Orlando Regional Healthcare, Orlando, Florida, USABackground. Hemophilia A is an X-linked recessive disorder characterized by defective synthesis of Factor VIII protein. Depending on the level of FVIII activity, patients may present with easy bruising, inadequate clotting of traumatic or mild injury, or in severe hemophilia, spontaneous hemorrhage. Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that is reported to have a decreased frequency of occurrence in subjects with coagulation disorders. Case. A 26-year-old white male with Hemophilia A was admitted for one month of rectal bleeding. The bleeding continued despite Factor VIII replacement and colonoscopy and biopsy were performed confirming the presence of active UC. Conclusion. Ulcerative colitis with underlying F VIII deficiency can result in serious, prolonged, and possibly fatal bleeding if left unrecognized and untreated. Treatment of both conditions concurrently utilizing tertiary facilities and consultations appears to be the safest strategy for management.http://dx.doi.org/10.1155/2018/2342618 |
| spellingShingle | Maxim Olivier Mario Madruga S. J. Carlan Li Ge Hemophilia A Complicated by Ulcerative Colitis Case Reports in Gastrointestinal Medicine |
| title | Hemophilia A Complicated by Ulcerative Colitis |
| title_full | Hemophilia A Complicated by Ulcerative Colitis |
| title_fullStr | Hemophilia A Complicated by Ulcerative Colitis |
| title_full_unstemmed | Hemophilia A Complicated by Ulcerative Colitis |
| title_short | Hemophilia A Complicated by Ulcerative Colitis |
| title_sort | hemophilia a complicated by ulcerative colitis |
| url | http://dx.doi.org/10.1155/2018/2342618 |
| work_keys_str_mv | AT maximolivier hemophiliaacomplicatedbyulcerativecolitis AT mariomadruga hemophiliaacomplicatedbyulcerativecolitis AT sjcarlan hemophiliaacomplicatedbyulcerativecolitis AT lige hemophiliaacomplicatedbyulcerativecolitis |