The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients
Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body’s immunity and increase the likelihood of cancer dissemination and metastasis. Anesth...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/7940603 |
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| author | Yangjie Dang Xingxing Shi William Xu Mingzhang Zuo |
| author_facet | Yangjie Dang Xingxing Shi William Xu Mingzhang Zuo |
| author_sort | Yangjie Dang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body’s immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance. |
| format | Article |
| id | doaj-art-d5f2c2157b3a4ef4a939dd4223c8fced |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-d5f2c2157b3a4ef4a939dd4223c8fced2025-02-03T01:01:12ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/79406037940603The Effect of Anesthesia on the Immune System in Colorectal Cancer PatientsYangjie Dang0Xingxing Shi1William Xu2Mingzhang Zuo3Department of Anesthesiology, Xi’an Children’s Hospital, Xi’an, Shaanxi 710032, ChinaDepartment of Anesthesiology, Xi’an Children’s Hospital, Xi’an, Shaanxi 710032, ChinaDepartment of Anesthesiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USADepartment of Anesthesiology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dongdan, Beijing 100730, ChinaColorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body’s immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance.http://dx.doi.org/10.1155/2018/7940603 |
| spellingShingle | Yangjie Dang Xingxing Shi William Xu Mingzhang Zuo The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients Canadian Journal of Gastroenterology and Hepatology |
| title | The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients |
| title_full | The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients |
| title_fullStr | The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients |
| title_full_unstemmed | The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients |
| title_short | The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients |
| title_sort | effect of anesthesia on the immune system in colorectal cancer patients |
| url | http://dx.doi.org/10.1155/2018/7940603 |
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