ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis

ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis

Abstract Background Lung adenocarcinoma (LUAD) remains a significant contributor to cancer incidence and mortality, with transcription factors playing pivotal roles in its progression and serving as potential therapeutic targets. Results Through an extensive analysis of expression data from over a t...

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Main Authors: Junkan Zhu, Shencheng Ren, Yanjun Yi, Zhiyao Wu, Han Lin, Guangyao Shan, Xiaolong Huang, Binyang Pan, Zhengyang Hu, Qihai Sui, Cheng Zhan, Shuai Wang, Jiaqi Liang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell & Bioscience
Subjects:
Lung adenocarcinoma
Apoptosis
Ferroptosis
Transcription factor
Targeted therapy
Online Access:https://doi.org/10.1186/s13578-025-01433-7
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