Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity
Bartonella henselae is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney in...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2018/9607582 |
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| author | Joseph Vercellone Lisa Cohen Saima Mansuri Ping L. Zhang Paul S. Kellerman |
| author_facet | Joseph Vercellone Lisa Cohen Saima Mansuri Ping L. Zhang Paul S. Kellerman |
| author_sort | Joseph Vercellone |
| collection | DOAJ |
| description | Bartonella henselae is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as B. henselae endocarditis. Bartonella endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Unique to our case in this series is a positive PR3-ANCA antibody despite a negative IIF-ANCA. Thus, the presentation of Bartonella can mimic ANCA-associated GN, and renal biopsy showing immune complex deposition is critical for diagnosis and appropriate treatment. |
| format | Article |
| id | doaj-art-d5e419bb894f476b80e38f25380624eb |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-d5e419bb894f476b80e38f25380624eb2025-02-03T06:13:36ZengWileyCase Reports in Nephrology2090-66412090-665X2018-01-01201810.1155/2018/96075829607582Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA PositivityJoseph Vercellone0Lisa Cohen1Saima Mansuri2Ping L. Zhang3Paul S. Kellerman4Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USADepartment of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USADepartment of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USADepartment of Pathology, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USADepartment of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USABartonella henselae is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as B. henselae endocarditis. Bartonella endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Unique to our case in this series is a positive PR3-ANCA antibody despite a negative IIF-ANCA. Thus, the presentation of Bartonella can mimic ANCA-associated GN, and renal biopsy showing immune complex deposition is critical for diagnosis and appropriate treatment.http://dx.doi.org/10.1155/2018/9607582 |
| spellingShingle | Joseph Vercellone Lisa Cohen Saima Mansuri Ping L. Zhang Paul S. Kellerman Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity Case Reports in Nephrology |
| title | Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity |
| title_full | Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity |
| title_fullStr | Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity |
| title_full_unstemmed | Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity |
| title_short | Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity |
| title_sort | bartonella endocarditis mimicking crescentic glomerulonephritis with pr3 anca positivity |
| url | http://dx.doi.org/10.1155/2018/9607582 |
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