Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma

Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report...

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Main Authors: Kaushik Mandal, Damilola Ashorobi, Alice Lee, Huijuan Liao, Salini C. Kumar, David S. Rosenthal
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Endocrinology
Online Access:http://dx.doi.org/10.1155/2021/8479193
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author Kaushik Mandal
Damilola Ashorobi
Alice Lee
Huijuan Liao
Salini C. Kumar
David S. Rosenthal
author_facet Kaushik Mandal
Damilola Ashorobi
Alice Lee
Huijuan Liao
Salini C. Kumar
David S. Rosenthal
author_sort Kaushik Mandal
collection DOAJ
description Sporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report an additional case of a patient with multiple myeloma and an IgG paraproteinemia who had such a spurious elevation of total T3 complicating her levothyroxine management of hypothyroidism. In addition, we alert clinicians that differences in performance characteristics between various manufacturers’ test platforms may also cause spurious reports.
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language English
publishDate 2021-01-01
publisher Wiley
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series Case Reports in Endocrinology
spelling doaj-art-d5e3162215014e2aaec72f7fbf839ef82025-02-03T01:08:58ZengWileyCase Reports in Endocrinology2090-65012090-651X2021-01-01202110.1155/2021/84791938479193Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple MyelomaKaushik Mandal0Damilola Ashorobi1Alice Lee2Huijuan Liao3Salini C. Kumar4David S. Rosenthal5Division of Endocrinology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Endocrinology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Endocrinology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Endocrinology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Endocrinology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Endocrinology, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USASporadic reports of factitious elevations of thyroid hormones related to laboratory interference from autoantibodies and multiple myeloma paraproteins have appeared in the literature. Such clinically confusing laboratory results can lead to erroneous diagnoses and inappropriate treatments. We report an additional case of a patient with multiple myeloma and an IgG paraproteinemia who had such a spurious elevation of total T3 complicating her levothyroxine management of hypothyroidism. In addition, we alert clinicians that differences in performance characteristics between various manufacturers’ test platforms may also cause spurious reports.http://dx.doi.org/10.1155/2021/8479193
spellingShingle Kaushik Mandal
Damilola Ashorobi
Alice Lee
Huijuan Liao
Salini C. Kumar
David S. Rosenthal
Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
Case Reports in Endocrinology
title Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_full Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_fullStr Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_full_unstemmed Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_short Factitiously Elevated Total Triiodothyronine in a Euthyroid Patient with Multiple Myeloma
title_sort factitiously elevated total triiodothyronine in a euthyroid patient with multiple myeloma
url http://dx.doi.org/10.1155/2021/8479193
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