Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India
Scrub Typhus has emerged as an important cause of acute febrile illness in various parts of India over the last decade. Scrub Typhus is caused by Orientia tsutsugamushi, a rickettsia transmitted through the bites of infected chigger larvae. The neurological manifestations of Scrub Typhus can be high...
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JCDR Research and Publications Private Limited
2025-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/20533/72611_CE[Ra1]_F(SS)_QC(PS_SS)_PF1(VD_SS)_redo_PFA(IS)_PB(IS)_PN(IS).pdf |
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| author | NR Salini T Sreena Sreekumar Sudharmma Ramakrishnan S Srikantan Jacob Antony |
| author_facet | NR Salini T Sreena Sreekumar Sudharmma Ramakrishnan S Srikantan Jacob Antony |
| author_sort | NR Salini |
| collection | DOAJ |
| description | Scrub Typhus has emerged as an important cause of acute febrile illness in various parts of India over the last decade. Scrub Typhus is caused by Orientia tsutsugamushi, a rickettsia transmitted through the bites of infected chigger larvae. The neurological manifestations of Scrub Typhus can be highly variable. The most common neurological manifestation is meningoencephalitis. In addition to two cases of meningoencephalitis, hereby, the authors report three different rare neurological manifestations of Scrub Typhus that presented in the second week of illness. These included isolated sixth cranial nerve palsy, opsoclonus myoclonus, and transient Parkinsonism. All the patients responded to treatment with doxycycline, and authors had to use steroids for one patient with opsoclonus myoclonus. A characteristic eschar was seen in only one patient out of the five cases. Therefore, a high index of suspicion for Scrub Typhus is needed in patients presenting with acute febrile illness and Central Nervous System (CNS) manifestations in endemic areas. |
| format | Article |
| id | doaj-art-d5e163674828486d95d20776ae3ed6dd |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-d5e163674828486d95d20776ae3ed6dd2025-01-25T12:12:52ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-01-011901010510.7860/JCDR/2025/72611.20533Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, IndiaNR Salini0T Sreena Sreekumar1Sudharmma Ramakrishnan2S Srikantan3Jacob Antony4Assistant Professor, Department of General Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.Assistant Professor, Department of General Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.Assistant Professor, Department of General Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.Professor, Department of General Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.Professor, Department of General Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.Scrub Typhus has emerged as an important cause of acute febrile illness in various parts of India over the last decade. Scrub Typhus is caused by Orientia tsutsugamushi, a rickettsia transmitted through the bites of infected chigger larvae. The neurological manifestations of Scrub Typhus can be highly variable. The most common neurological manifestation is meningoencephalitis. In addition to two cases of meningoencephalitis, hereby, the authors report three different rare neurological manifestations of Scrub Typhus that presented in the second week of illness. These included isolated sixth cranial nerve palsy, opsoclonus myoclonus, and transient Parkinsonism. All the patients responded to treatment with doxycycline, and authors had to use steroids for one patient with opsoclonus myoclonus. A characteristic eschar was seen in only one patient out of the five cases. Therefore, a high index of suspicion for Scrub Typhus is needed in patients presenting with acute febrile illness and Central Nervous System (CNS) manifestations in endemic areas.https://jcdr.net/articles/PDF/20533/72611_CE[Ra1]_F(SS)_QC(PS_SS)_PF1(VD_SS)_redo_PFA(IS)_PB(IS)_PN(IS).pdfmeningoencephalitisopsoclonusorientia tsutsugamushiparkinsonism |
| spellingShingle | NR Salini T Sreena Sreekumar Sudharmma Ramakrishnan S Srikantan Jacob Antony Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India Journal of Clinical and Diagnostic Research meningoencephalitis opsoclonus orientia tsutsugamushi parkinsonism |
| title | Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India |
| title_full | Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India |
| title_fullStr | Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India |
| title_full_unstemmed | Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India |
| title_short | Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India |
| title_sort | rare neurological manifestations of scrub typhus case series from a tertiary care centre in kerala india |
| topic | meningoencephalitis opsoclonus orientia tsutsugamushi parkinsonism |
| url | https://jcdr.net/articles/PDF/20533/72611_CE[Ra1]_F(SS)_QC(PS_SS)_PF1(VD_SS)_redo_PFA(IS)_PB(IS)_PN(IS).pdf |
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