The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases
Posttranslational modification of proteins by ubiquitin has emerged as a critical regulator of synapse development and function. Ubiquitination is a reversible modification mediated by the concerted action of a large number of specific ubiquitin ligases and ubiquitin proteases, called deubiquitinati...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/892749 |
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| author | Jennifer R. Kowalski Peter Juo |
| author_facet | Jennifer R. Kowalski Peter Juo |
| author_sort | Jennifer R. Kowalski |
| collection | DOAJ |
| description | Posttranslational modification of proteins by ubiquitin has emerged as a critical regulator of synapse development and function. Ubiquitination is a reversible modification mediated by the concerted action of a large number of specific ubiquitin ligases and ubiquitin proteases, called deubiquitinating enzymes (DUBs). The balance of activity of these enzymes determines the localization, function, and stability of target proteins. While some DUBs counter the action of specific ubiquitin ligases by removing ubiquitin and editing ubiquitin chains, other DUBs function more generally to maintain the cellular pool of free ubiquitin monomers. The importance of DUB function at the synapse is underscored by the association of specific mutations in DUB genes with several neurological disorders. Over the last decade, although much research has led to the identification and characterization of many ubiquitin ligases at the synapse, our knowledge of the relevant DUBs that act at the synapse has lagged. This review is focused on highlighting our current understanding of DUBs that regulate synaptic function and the diseases that result from dysfunction of these DUBs. |
| format | Article |
| id | doaj-art-d5e10e8780954f43ae074712617e4bbd |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-d5e10e8780954f43ae074712617e4bbd2025-02-03T01:23:08ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/892749892749The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System DiseasesJennifer R. Kowalski0Peter Juo1Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, IN 46208, USADepartment of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USAPosttranslational modification of proteins by ubiquitin has emerged as a critical regulator of synapse development and function. Ubiquitination is a reversible modification mediated by the concerted action of a large number of specific ubiquitin ligases and ubiquitin proteases, called deubiquitinating enzymes (DUBs). The balance of activity of these enzymes determines the localization, function, and stability of target proteins. While some DUBs counter the action of specific ubiquitin ligases by removing ubiquitin and editing ubiquitin chains, other DUBs function more generally to maintain the cellular pool of free ubiquitin monomers. The importance of DUB function at the synapse is underscored by the association of specific mutations in DUB genes with several neurological disorders. Over the last decade, although much research has led to the identification and characterization of many ubiquitin ligases at the synapse, our knowledge of the relevant DUBs that act at the synapse has lagged. This review is focused on highlighting our current understanding of DUBs that regulate synaptic function and the diseases that result from dysfunction of these DUBs.http://dx.doi.org/10.1155/2012/892749 |
| spellingShingle | Jennifer R. Kowalski Peter Juo The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases Neural Plasticity |
| title | The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases |
| title_full | The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases |
| title_fullStr | The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases |
| title_full_unstemmed | The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases |
| title_short | The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases |
| title_sort | role of deubiquitinating enzymes in synaptic function and nervous system diseases |
| url | http://dx.doi.org/10.1155/2012/892749 |
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