Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process
Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorder...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/4120973 |
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| author | Urszula Grzybowska-Chlebowczyk Paulina Wysocka-Wojakiewicz Martyna Jasielska Bożena Cukrowska Sabina Więcek Maria Kniażewska Jerzy Chudek |
| author_facet | Urszula Grzybowska-Chlebowczyk Paulina Wysocka-Wojakiewicz Martyna Jasielska Bożena Cukrowska Sabina Więcek Maria Kniażewska Jerzy Chudek |
| author_sort | Urszula Grzybowska-Chlebowczyk |
| collection | DOAJ |
| description | Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorders (FGID). The prospective study included a group of 71 children during a period of 2 years. In all children, laboratory tests were performed and intima-media complex in the carotid artery was measured (IMC). Low values of OS were more frequent in children with IBD than in the FGID group. The average concentration of oxidized lipoprotein with average density (oxLDL) was lower in patients with IBD. Among patients with IBD, higher concentrations of oxLDL were recorded in patients with longer-duration disease and with higher concentrations of total cholesterol. In the IBD group, more often, higher concentrations of anti-oxLDL were recorded among patients with longer-duration disease. The obtained results did not support the hypothesis of total antioxidant capacity depletion and greater overall OS in patients with IBD. Patients with IBD with a longer duration of the disease have higher concentrations of oxLDL and anti-oxLDL. |
| format | Article |
| id | doaj-art-d5d2fa95f0df466694a0517fa1d8e0e4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d5d2fa95f0df466694a0517fa1d8e0e42025-02-03T01:12:26ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/41209734120973Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory ProcessUrszula Grzybowska-Chlebowczyk0Paulina Wysocka-Wojakiewicz1Martyna Jasielska2Bożena Cukrowska3Sabina Więcek4Maria Kniażewska5Jerzy Chudek6Department of Pediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandUpper Silesian Child Health Center, Katowice, PolandUpper Silesian Child Health Center, Katowice, PolandDepartment of Pathology, The Children’s Memorial Health Institute, Warsaw, PolandDepartment of Pediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandUpper Silesian Child Health Center, Katowice, PolandDepartment of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandOxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorders (FGID). The prospective study included a group of 71 children during a period of 2 years. In all children, laboratory tests were performed and intima-media complex in the carotid artery was measured (IMC). Low values of OS were more frequent in children with IBD than in the FGID group. The average concentration of oxidized lipoprotein with average density (oxLDL) was lower in patients with IBD. Among patients with IBD, higher concentrations of oxLDL were recorded in patients with longer-duration disease and with higher concentrations of total cholesterol. In the IBD group, more often, higher concentrations of anti-oxLDL were recorded among patients with longer-duration disease. The obtained results did not support the hypothesis of total antioxidant capacity depletion and greater overall OS in patients with IBD. Patients with IBD with a longer duration of the disease have higher concentrations of oxLDL and anti-oxLDL.http://dx.doi.org/10.1155/2018/4120973 |
| spellingShingle | Urszula Grzybowska-Chlebowczyk Paulina Wysocka-Wojakiewicz Martyna Jasielska Bożena Cukrowska Sabina Więcek Maria Kniażewska Jerzy Chudek Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process Mediators of Inflammation |
| title | Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process |
| title_full | Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process |
| title_fullStr | Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process |
| title_full_unstemmed | Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process |
| title_short | Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process |
| title_sort | oxidative and antioxidative stress status in children with inflammatory bowel disease as a result of a chronic inflammatory process |
| url | http://dx.doi.org/10.1155/2018/4120973 |
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