Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T
Background and purpose: This study aims to evaluate the neurochemical characteristics of pathological tissues by 1H magnetic resonance spectroscopy (MRS) in patient with pharmaco-resistant focal epilepsy at 7 T. Methods: Thirteen patients with drug-resistant epilepsy and focal seizure successfully u...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | European Journal of Radiology Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047725000073 |
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| author | Lijing Xin Philippe Reymond José Boto Frederic Grouiller Serge Vulliemoz Francois Lazeyras Maria Isabel Vargas |
| author_facet | Lijing Xin Philippe Reymond José Boto Frederic Grouiller Serge Vulliemoz Francois Lazeyras Maria Isabel Vargas |
| author_sort | Lijing Xin |
| collection | DOAJ |
| description | Background and purpose: This study aims to evaluate the neurochemical characteristics of pathological tissues by 1H magnetic resonance spectroscopy (MRS) in patient with pharmaco-resistant focal epilepsy at 7 T. Methods: Thirteen patients with drug-resistant epilepsy and focal seizure successfully underwent MRS examinations at 7 T MRI scanners. 1H MR spectra were acquired from two voxels (lesion side and contralateral side) using the semi-adiabatic spin-echo full-intensity localized spectroscopy (sSPECIAL) sequence. Metabolite levels were quantified from LCModel and reported as to total creatine ratio. Results: In comparison to the contralateral side, lesions in focal cortical dysplasia demonstrated significantly reduced macromolecule and N-acetyl aspartate, significantly increased total choline and glycine + myo-inositol, and a distinct reduction trend of glutamate. Conclusions: We conclude that performing MRS at high magnetic field offered the potential to reveal metabolic alterations in epilepsy lesions that may help to further understand the underlying pathophysiology of the disease. |
| format | Article |
| id | doaj-art-d5ca4b2e6d1a4e7c8ea52cf6edf855f2 |
| institution | DOAJ |
| issn | 2352-0477 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj-art-d5ca4b2e6d1a4e7c8ea52cf6edf855f22025-08-20T02:54:59ZengElsevierEuropean Journal of Radiology Open2352-04772025-06-011410064010.1016/j.ejro.2025.100640Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 TLijing Xin0Philippe Reymond1José Boto2Frederic Grouiller3Serge Vulliemoz4Francois Lazeyras5Maria Isabel Vargas6Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, SwitzerlandDivision of Neuroradiology, Geneva University Hospitals and University of Geneva, SwitzerlandDivision of Neuroradiology, Geneva University Hospitals and University of Geneva, SwitzerlandSwiss Center of Affective Sciences, University of Geneva, Switzerland; Center for Biomedical Imaging of Geneva and University of Geneva, SwitzerlandDivision of Neurology, Neurosciences Department of Geneva University Hospitals and University of Geneva, SwitzerlandCenter for Biomedical Imaging of Geneva and University of Geneva, SwitzerlandClinique des Grangettes-Hirslanden and University of Geneva, Switzerland; Correspondence to: Clinique des Grangettes, Chemin des Grangettes, 7, Chêne Bougeries 1224, Switzerland.Background and purpose: This study aims to evaluate the neurochemical characteristics of pathological tissues by 1H magnetic resonance spectroscopy (MRS) in patient with pharmaco-resistant focal epilepsy at 7 T. Methods: Thirteen patients with drug-resistant epilepsy and focal seizure successfully underwent MRS examinations at 7 T MRI scanners. 1H MR spectra were acquired from two voxels (lesion side and contralateral side) using the semi-adiabatic spin-echo full-intensity localized spectroscopy (sSPECIAL) sequence. Metabolite levels were quantified from LCModel and reported as to total creatine ratio. Results: In comparison to the contralateral side, lesions in focal cortical dysplasia demonstrated significantly reduced macromolecule and N-acetyl aspartate, significantly increased total choline and glycine + myo-inositol, and a distinct reduction trend of glutamate. Conclusions: We conclude that performing MRS at high magnetic field offered the potential to reveal metabolic alterations in epilepsy lesions that may help to further understand the underlying pathophysiology of the disease.http://www.sciencedirect.com/science/article/pii/S2352047725000073EpilepsyMR spectroscopyNon lesional7 TCortical dysplasia |
| spellingShingle | Lijing Xin Philippe Reymond José Boto Frederic Grouiller Serge Vulliemoz Francois Lazeyras Maria Isabel Vargas Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T European Journal of Radiology Open Epilepsy MR spectroscopy Non lesional 7 T Cortical dysplasia |
| title | Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T |
| title_full | Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T |
| title_fullStr | Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T |
| title_full_unstemmed | Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T |
| title_short | Neurochemical characteristics of pathological tissues in epilepsy: A preliminary 1H MR spectroscopy study at 7 T |
| title_sort | neurochemical characteristics of pathological tissues in epilepsy a preliminary 1h mr spectroscopy study at 7 t |
| topic | Epilepsy MR spectroscopy Non lesional 7 T Cortical dysplasia |
| url | http://www.sciencedirect.com/science/article/pii/S2352047725000073 |
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