Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM)
Study objective: to estimate efficiency of atorvastatin therapy in patients with type 2 diabetes mellitus (T2DM), who are the carrier of various genotypes Q192R paraoxonase gene 1 (PON1). 386 T2DM patients, who have not received statin therapy before, and 187 healthy people were examined. All those...
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Academician I.P. Pavlov First St. Petersburg State Medical University
2015-03-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/122 |
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| author | M. V. Kim S. A. Skoryukova A. A. Bystrova E. I. Baranova S. N. Pchelina |
| author_facet | M. V. Kim S. A. Skoryukova A. A. Bystrova E. I. Baranova S. N. Pchelina |
| author_sort | M. V. Kim |
| collection | DOAJ |
| description | Study objective: to estimate efficiency of atorvastatin therapy in patients with type 2 diabetes mellitus (T2DM), who are the carrier of various genotypes Q192R paraoxonase gene 1 (PON1). 386 T2DM patients, who have not received statin therapy before, and 187 healthy people were examined. All those examined were exposed to blood lipid profile testing and molecular genetic research. The atorvastatin treatment group included 164 T2DM patients with abnormality of lipids, their blood lipid profile values were assessed before and after 3 months of the therapy. Blood lipid profile values did not differ in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism. Atorvastatin therapy decreased atherogenic lipoprotein levels in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism, but reduction degree in the carriers of different Q192R genotypes differed - in Q192Q bearers it was greater than in the bearers of Q192R genotype of gene PON1 (р = 0,031). Atorvastatin 3-months therapy revealed greater reduction of total cholesterol in the carriers of Q192Q genotype of gene 1 (PON1) than in the carriers of Q192R genotype of gene 1 (PON1). |
| format | Article |
| id | doaj-art-d5a42e8e77eb475aa35fbc12d825f06b |
| institution | DOAJ |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2015-03-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-d5a42e8e77eb475aa35fbc12d825f06b2025-08-20T03:00:37ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072015-03-01221869110.24884/1607-4181-2015-22-1-86-91118Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM)M. V. Kim0S. A. Skoryukova1A. A. Bystrova2E. I. Baranova3S. N. Pchelina4Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Северо-Западный федеральный медицинский исследовательский центр Министерства здравоохранения Российской ФедерацииПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Северо-Западный федеральный медицинский исследовательский центр Министерства здравоохранения Российской ФедерацииПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Северо-Западный федеральный медицинский исследовательский центр Министерства здравоохранения Российской ФедерацииПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Северо-Западный федеральный медицинский исследовательский центр Министерства здравоохранения Российской ФедерацииПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Северо-Западный федеральный медицинский исследовательский центр Министерства здравоохранения Российской ФедерацииStudy objective: to estimate efficiency of atorvastatin therapy in patients with type 2 diabetes mellitus (T2DM), who are the carrier of various genotypes Q192R paraoxonase gene 1 (PON1). 386 T2DM patients, who have not received statin therapy before, and 187 healthy people were examined. All those examined were exposed to blood lipid profile testing and molecular genetic research. The atorvastatin treatment group included 164 T2DM patients with abnormality of lipids, their blood lipid profile values were assessed before and after 3 months of the therapy. Blood lipid profile values did not differ in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism. Atorvastatin therapy decreased atherogenic lipoprotein levels in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism, but reduction degree in the carriers of different Q192R genotypes differed - in Q192Q bearers it was greater than in the bearers of Q192R genotype of gene PON1 (р = 0,031). Atorvastatin 3-months therapy revealed greater reduction of total cholesterol in the carriers of Q192Q genotype of gene 1 (PON1) than in the carriers of Q192R genotype of gene 1 (PON1).https://www.sci-notes.ru/jour/article/view/122сахарный диабетдислипидемияген параоксоназы 1аторвастатинdiabetes mellitusdyslipidemiaparaoxonase 1 geneatorvastatin |
| spellingShingle | M. V. Kim S. A. Skoryukova A. A. Bystrova E. I. Baranova S. N. Pchelina Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM) Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова сахарный диабет дислипидемия ген параоксоназы 1 аторвастатин diabetes mellitus dyslipidemia paraoxonase 1 gene atorvastatin |
| title | Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM) |
| title_full | Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM) |
| title_fullStr | Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM) |
| title_full_unstemmed | Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM) |
| title_short | Q192R paraoxonase gene 1 (PON1) polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus (T2DM) |
| title_sort | q192r paraoxonase gene 1 pon1 polymorphism and atorvastatin therapy effect in patients with type 2 diabetes mellitus t2dm |
| topic | сахарный диабет дислипидемия ген параоксоназы 1 аторвастатин diabetes mellitus dyslipidemia paraoxonase 1 gene atorvastatin |
| url | https://www.sci-notes.ru/jour/article/view/122 |
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