The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals
The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-prolifera...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1728278 |
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| _version_ | 1832562011479736320 |
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| author | Zezheng Pan Mengli Sun Xia Liang Jia Li Fangyue Zhou Zhisheng Zhong Yuehui Zheng |
| author_facet | Zezheng Pan Mengli Sun Xia Liang Jia Li Fangyue Zhou Zhisheng Zhong Yuehui Zheng |
| author_sort | Zezheng Pan |
| collection | DOAJ |
| description | The conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. Herein, we review the research history and discovery of putative female germline stem cells, the concept that putative germline stem cells exist in the postnatal mammalian ovary, and the research progress, challenge, and application of putative germline stem cells in recent years. |
| format | Article |
| id | doaj-art-d58d70c93e59489787eb5aebf313e145 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d58d70c93e59489787eb5aebf313e1452025-02-03T01:23:41ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/17282781728278The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in MammalsZezheng Pan0Mengli Sun1Xia Liang2Jia Li3Fangyue Zhou4Zhisheng Zhong5Yuehui Zheng6Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaMedical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaMedical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaMedical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaMedical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaThe Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330006, ChinaMedical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaThe conventional view is that female mammals lose their ability to generate new germ cells after birth. However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. Herein, we review the research history and discovery of putative female germline stem cells, the concept that putative germline stem cells exist in the postnatal mammalian ovary, and the research progress, challenge, and application of putative germline stem cells in recent years.http://dx.doi.org/10.1155/2016/1728278 |
| spellingShingle | Zezheng Pan Mengli Sun Xia Liang Jia Li Fangyue Zhou Zhisheng Zhong Yuehui Zheng The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals Stem Cells International |
| title | The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals |
| title_full | The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals |
| title_fullStr | The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals |
| title_full_unstemmed | The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals |
| title_short | The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals |
| title_sort | controversy challenges and potential benefits of putative female germline stem cells research in mammals |
| url | http://dx.doi.org/10.1155/2016/1728278 |
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