The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks
For several years, lipids and especially 𝑛−3 and 𝑛−6 polyunsaturated fatty acids (PUFAs) receive much attention in human health. Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer. However, the molecular and cellular mechanisms...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/712536 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561667128426496 |
|---|---|
| author | Benoît Chénais Vincent Blanckaert |
| author_facet | Benoît Chénais Vincent Blanckaert |
| author_sort | Benoît Chénais |
| collection | DOAJ |
| description | For several years, lipids and especially 𝑛−3 and 𝑛−6
polyunsaturated fatty acids (PUFAs) receive much attention in human health. Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer. However, the molecular and cellular mechanisms supporting the effect of PUFAs in breast cancer cells remain relatively unknown. Here, we review some recent progress in understanding the impact that PUFA may have on breast cancer cell proliferation, apoptosis, migration, and invasion. While most of the results obtained with docosahexaenoic acid and/or eicosapentaenoic acid show a decrease of tumor cell proliferation and/or aggressivity, there is some evidence that other lipids, which accumulate in breast cancer tissues, such as arachidonic acid may have opposite effects. Finally, lipids and especially PUFAs appear as potential adjuvants to conventional cancer therapy. |
| format | Article |
| id | doaj-art-d575a84e64ee41ddaafe99b24cd55016 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-d575a84e64ee41ddaafe99b24cd550162025-02-03T01:24:34ZengWileyInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/712536712536The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell HallmarksBenoît Chénais0Vincent Blanckaert1EA2160, Mer Molécules Santé, Université du Maine, Avenue Olivier Messiaen, 72085 Le Mans, FranceEA2160, Mer Molécules Santé, Université du Maine, Avenue Olivier Messiaen, 72085 Le Mans, FranceFor several years, lipids and especially 𝑛−3 and 𝑛−6 polyunsaturated fatty acids (PUFAs) receive much attention in human health. Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer. However, the molecular and cellular mechanisms supporting the effect of PUFAs in breast cancer cells remain relatively unknown. Here, we review some recent progress in understanding the impact that PUFA may have on breast cancer cell proliferation, apoptosis, migration, and invasion. While most of the results obtained with docosahexaenoic acid and/or eicosapentaenoic acid show a decrease of tumor cell proliferation and/or aggressivity, there is some evidence that other lipids, which accumulate in breast cancer tissues, such as arachidonic acid may have opposite effects. Finally, lipids and especially PUFAs appear as potential adjuvants to conventional cancer therapy.http://dx.doi.org/10.1155/2012/712536 |
| spellingShingle | Benoît Chénais Vincent Blanckaert The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks International Journal of Breast Cancer |
| title | The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks |
| title_full | The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks |
| title_fullStr | The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks |
| title_full_unstemmed | The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks |
| title_short | The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks |
| title_sort | janus face of lipids in human breast cancer how polyunsaturated fatty acids affect tumor cell hallmarks |
| url | http://dx.doi.org/10.1155/2012/712536 |
| work_keys_str_mv | AT benoitchenais thejanusfaceoflipidsinhumanbreastcancerhowpolyunsaturatedfattyacidsaffecttumorcellhallmarks AT vincentblanckaert thejanusfaceoflipidsinhumanbreastcancerhowpolyunsaturatedfattyacidsaffecttumorcellhallmarks AT benoitchenais janusfaceoflipidsinhumanbreastcancerhowpolyunsaturatedfattyacidsaffecttumorcellhallmarks AT vincentblanckaert janusfaceoflipidsinhumanbreastcancerhowpolyunsaturatedfattyacidsaffecttumorcellhallmarks |