Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions
We compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12–20 weeks' gestation and 133 nonpregnant controls had vaginal co...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2010/385981 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557060580966400 |
|---|---|
| author | Jennifer Balkus Kathy Agnew Richard Lawler Caroline Mitchell Jane Hitti |
| author_facet | Jennifer Balkus Kathy Agnew Richard Lawler Caroline Mitchell Jane Hitti |
| author_sort | Jennifer Balkus |
| collection | DOAJ |
| description | We compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12–20 weeks' gestation and 133 nonpregnant controls had vaginal concentrations of interleukin (IL)-1β, IL-6, IL-8, and SLPI measured by enzyme immunoassay. Multivariable linear regression was used to evaluate factors independently associated with vaginal cytokine and SLPI response. Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations. |
| format | Article |
| id | doaj-art-d56795d3ee9744ca804c3255bb86947d |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-d56795d3ee9744ca804c3255bb86947d2025-02-03T05:43:51ZengWileyJournal of Pregnancy2090-27272090-27352010-01-01201010.1155/2010/385981385981Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal SecretionsJennifer Balkus0Kathy Agnew1Richard Lawler2Caroline Mitchell3Jane Hitti4Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USADepartment of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USAFred Hutchinson Cancer Research Centers, Seattle, 98109 WA, USADepartment of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USADepartment of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USAWe compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12–20 weeks' gestation and 133 nonpregnant controls had vaginal concentrations of interleukin (IL)-1β, IL-6, IL-8, and SLPI measured by enzyme immunoassay. Multivariable linear regression was used to evaluate factors independently associated with vaginal cytokine and SLPI response. Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations.http://dx.doi.org/10.1155/2010/385981 |
| spellingShingle | Jennifer Balkus Kathy Agnew Richard Lawler Caroline Mitchell Jane Hitti Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions Journal of Pregnancy |
| title | Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions |
| title_full | Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions |
| title_fullStr | Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions |
| title_full_unstemmed | Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions |
| title_short | Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions |
| title_sort | effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions |
| url | http://dx.doi.org/10.1155/2010/385981 |
| work_keys_str_mv | AT jenniferbalkus effectsofpregnancyandbacterialvaginosisonproinflammatorycytokineandsecretoryleukocyteproteaseinhibitorconcentrationsinvaginalsecretions AT kathyagnew effectsofpregnancyandbacterialvaginosisonproinflammatorycytokineandsecretoryleukocyteproteaseinhibitorconcentrationsinvaginalsecretions AT richardlawler effectsofpregnancyandbacterialvaginosisonproinflammatorycytokineandsecretoryleukocyteproteaseinhibitorconcentrationsinvaginalsecretions AT carolinemitchell effectsofpregnancyandbacterialvaginosisonproinflammatorycytokineandsecretoryleukocyteproteaseinhibitorconcentrationsinvaginalsecretions AT janehitti effectsofpregnancyandbacterialvaginosisonproinflammatorycytokineandsecretoryleukocyteproteaseinhibitorconcentrationsinvaginalsecretions |