Utility of the TG/HDL-C Ratio in Estimating Pediatric Cardiometabolic Risk in a Community Hospital

Utility of the TG/HDL-C Ratio in Estimating Pediatric Cardiometabolic Risk in a Community Hospital

<b>Background</b>: The evaluation of metabolic syndrome (MetS) is critical among children and adolescents as it can predict cardiovascular disease in adulthood. The TG/HDL-C ratio has the best predictive accuracy among the different lipid ratios. This study aims to evaluate the prevalenc...

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Bibliographic Details
Main Authors: Adeola O. Awujoola, Ana P. Torga, Jose E. Valencia, Hermella Alemneh, Olaseni P. Prince, Sandipagu P. Kant
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Children
Subjects:
metabolic syndrome
cardiovascular disease
triglyceride
high-density lipoprotein cholesterol
Online Access:https://www.mdpi.com/2227-9067/11/11/1277
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Summary:<b>Background</b>: The evaluation of metabolic syndrome (MetS) is critical among children and adolescents as it can predict cardiovascular disease in adulthood. The TG/HDL-C ratio has the best predictive accuracy among the different lipid ratios. This study aims to evaluate the prevalence and factors associated with a high TG/HDL-C ratio and the predictive accuracy for pediatric MetS. <b>Methods</b>: This is a cross-sectional study of adolescents aged 9–21 to determine the prevalence of and associations between an elevated TG/HDL-C ratio and MetS. A ROC curve analysis was performed to determine the predictive accuracy of TG/HDL-C with MetS. <b>Results</b>: Of the 604 subjects, 29.8% had elevated TG/HDL-C, MetS was identified in 28.2%, and 54.5% were obese. Among patients with MetS, those with obesity were more likely to have an elevated TG/HDL-C ratio compared to those with a normal BMI (64% vs. 14%, <i>p</i> < 0.05). Gender, obesity, ethnicity, and METS are significantly associated with a high TG/HDL-C ratio. TG/HDL-C has a good discriminatory ability to distinguish patients with MetS from those without (AUC 0.65, <i>p</i> < 0.05). <b>Conclusions</b>: The TG/HDL-C ratio was able to distinguish between children and adolescents with MetS. Hence, the TG/HDL-C ratio may be used in the rapid risk assessment of pediatric MetS, especially in those with obesity.
ISSN:2227-9067

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