Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry
Background. While increasing evidence suggests comorbidity of peripheral neuropathy (PNP) and Parkinson’s disease (PD), the pathogenesis of PNP in PD is still a debate. The aim of this article is to search the core PD symptoms such as rigidity and tremor as contributing factors to mononeuropathy dev...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/4958068 |
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| author | Nilgul Yardimci Ozlem Cemeroglu Eda Ozturk Gülsüm Gürlü Esra Şahin Saliha Bozkurt Tugba Cengiz Gulderen Karali Hasim Cakirbay Atilla İlhan |
| author_facet | Nilgul Yardimci Ozlem Cemeroglu Eda Ozturk Gülsüm Gürlü Esra Şahin Saliha Bozkurt Tugba Cengiz Gulderen Karali Hasim Cakirbay Atilla İlhan |
| author_sort | Nilgul Yardimci |
| collection | DOAJ |
| description | Background. While increasing evidence suggests comorbidity of peripheral neuropathy (PNP) and Parkinson’s disease (PD), the pathogenesis of PNP in PD is still a debate. The aim of this article is to search the core PD symptoms such as rigidity and tremor as contributing factors to mononeuropathy development while emphasizing each individual patient’s asymmetric symptom severity. Methods. We studied 62 wrists and 62 elbows of 31 patients (mean age 66.48±10.67) and 64 wrists and 64 elbows of 32 age-gender matched healthy controls (mean age 62.03±10.40, p=0.145). The Hoehn and Yahr disability scale and Unified Parkinson’s Disease Rated Scale were used to determine the severity of the disease. Results. According to electrodiagnostic criteria, we confirmed median neuropathy in 16.12% (bilateral in two-thirds of the patients) and ulnar neuropathy in 3.22% of the PD group. While mean age (p=0.003), age at PD onset (p=0.019), and H&Y scores (p=0.016) were significant, tremor and rigidity scores were not. The comparison of the mean indices of electrophysiologic parameters indicated subclinical median and ulnar nerve demyelination both at the wrist and at the elbow in the patient groups where a longer disease duration and mild tremor and rigidity scores are prominent, remarkably. Conclusion. A disease related peripheral neurodegeneration beyond symptom severity occurs in PD. |
| format | Article |
| id | doaj-art-d5384fe01afe4ef083e0403d9b8a0b37 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-d5384fe01afe4ef083e0403d9b8a0b372025-02-03T05:53:56ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/49580684958068Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and AsymmetryNilgul Yardimci0Ozlem Cemeroglu1Eda Ozturk2Gülsüm Gürlü3Esra Şahin4Saliha Bozkurt5Tugba Cengiz6Gulderen Karali7Hasim Cakirbay8Atilla İlhan9Neurology Department, Minasera Aldan Hospital, Ahmet Taner Kislali Mah. 2741, Street No. 2 Cayyolu, Ankara, TurkeyPhysical Medicine and Rehabilitation Department, Medical Park Ankara Hospital, Kentkoop Mah., Kentkoop Parkici Yolu, Yenimahalle, Ankara, TurkeyBiostatistics Department, Medicine Faculty, Hacettepe University, Hacettepe Mah., 06230 Ankara, TurkeyPhysical Medicine and Rehabilitation Department, Medicine Faculty, Turgut Ozal University, Alparslan Turkes Cad. No. 57, Emek, 06510 Ankara, TurkeyPhysical Medicine and Rehabilitation Department, Medicine Faculty, Turgut Ozal University, Alparslan Turkes Cad. No. 57, Emek, 06510 Ankara, TurkeyPhysical Medicine and Rehabilitation Department, Medicine Faculty, Turgut Ozal University, Alparslan Turkes Cad. No. 57, Emek, 06510 Ankara, TurkeyNeurology Department, Medicine Faculty, Turgut Ozal University, Alparslan Turkes Cad. No. 57, Emek, 06510 Ankara, TurkeyNeurology Department, Medicine Faculty, Turgut Ozal University, Alparslan Turkes Cad. No. 57, Emek, 06510 Ankara, TurkeyPhysical Medicine and Rehabilitation Department, Medical Park Ankara Hospital, Kentkoop Mah., Kentkoop Parkici Yolu, Yenimahalle, Ankara, TurkeyNeurology Department, Medicine Faculty, Gazi University, Emniyet, Yenimahalle, 06560 Ankara, TurkeyBackground. While increasing evidence suggests comorbidity of peripheral neuropathy (PNP) and Parkinson’s disease (PD), the pathogenesis of PNP in PD is still a debate. The aim of this article is to search the core PD symptoms such as rigidity and tremor as contributing factors to mononeuropathy development while emphasizing each individual patient’s asymmetric symptom severity. Methods. We studied 62 wrists and 62 elbows of 31 patients (mean age 66.48±10.67) and 64 wrists and 64 elbows of 32 age-gender matched healthy controls (mean age 62.03±10.40, p=0.145). The Hoehn and Yahr disability scale and Unified Parkinson’s Disease Rated Scale were used to determine the severity of the disease. Results. According to electrodiagnostic criteria, we confirmed median neuropathy in 16.12% (bilateral in two-thirds of the patients) and ulnar neuropathy in 3.22% of the PD group. While mean age (p=0.003), age at PD onset (p=0.019), and H&Y scores (p=0.016) were significant, tremor and rigidity scores were not. The comparison of the mean indices of electrophysiologic parameters indicated subclinical median and ulnar nerve demyelination both at the wrist and at the elbow in the patient groups where a longer disease duration and mild tremor and rigidity scores are prominent, remarkably. Conclusion. A disease related peripheral neurodegeneration beyond symptom severity occurs in PD.http://dx.doi.org/10.1155/2016/4958068 |
| spellingShingle | Nilgul Yardimci Ozlem Cemeroglu Eda Ozturk Gülsüm Gürlü Esra Şahin Saliha Bozkurt Tugba Cengiz Gulderen Karali Hasim Cakirbay Atilla İlhan Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry Parkinson's Disease |
| title | Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry |
| title_full | Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry |
| title_fullStr | Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry |
| title_full_unstemmed | Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry |
| title_short | Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry |
| title_sort | median and ulnar neuropathy assessment in parkinson s disease regarding symptom severity and asymmetry |
| url | http://dx.doi.org/10.1155/2016/4958068 |
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