Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes
Background and Aim: Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant impact on fertilization success and...
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Kurdistan University of Medical Sciences
2024-11-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
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| Online Access: | http://sjku.muk.ac.ir/article-1-8161-en.pdf |
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| author | Nabaz abasi shiva khalesro Erfan daneshi |
| author_facet | Nabaz abasi shiva khalesro Erfan daneshi |
| author_sort | Nabaz abasi |
| collection | DOAJ |
| description | Background and Aim: Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant impact on fertilization success and embryo development. The current study aimed to investigate the effect of Borago officinalis L extract on serum testosterone levels, sperm parameters, in the streptozotocin (STZ)-induced mouse model of diabetes.
Materials and Methods: In this research, 30 male mice were randomly divided in 3 groups control, diabetic (Streptozotocin 150 mg/kg) and diabetic + Borago officinalis L (400 mg/kg) groups. After 6 weeks of treatment, the mice were sacrificed and in each group of mice, sperm parameters and testosterone were measured
Results: The results revealed a decrease in body and testis weight and elevated blood FBS levels in the diabetic group, compared to the control. However, Borago treatment significantly increased body and testis weight, while serum FBS levels were decreased, in comparison to the diabetic group. In addition, Borago significantly increased blood testosterone levels, compared to the diabetic group.
Conclusion: The present study showed that, Borago officinalis in male mice has a healing effect on sperm parameters against the damage of diabetes |
| format | Article |
| id | doaj-art-d5373bdb3a844d468e9372b21e9a4399 |
| institution | Kabale University |
| issn | 1560-652X 2345-4040 |
| language | fas |
| publishDate | 2024-11-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj-art-d5373bdb3a844d468e9372b21e9a43992025-02-01T09:41:40ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402024-11-01295111Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetesNabaz abasi0shiva khalesro1Erfan daneshi2 Msc , Department of Plant Production and Genetics, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran Associate professor, Department of Plant Production and Genetics, Faculty of Agriculture, University of Kurdistan Sanandaj, Iran Associate professor, Cellular and Molecular Research Center Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran Background and Aim: Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant impact on fertilization success and embryo development. The current study aimed to investigate the effect of Borago officinalis L extract on serum testosterone levels, sperm parameters, in the streptozotocin (STZ)-induced mouse model of diabetes. Materials and Methods: In this research, 30 male mice were randomly divided in 3 groups control, diabetic (Streptozotocin 150 mg/kg) and diabetic + Borago officinalis L (400 mg/kg) groups. After 6 weeks of treatment, the mice were sacrificed and in each group of mice, sperm parameters and testosterone were measured Results: The results revealed a decrease in body and testis weight and elevated blood FBS levels in the diabetic group, compared to the control. However, Borago treatment significantly increased body and testis weight, while serum FBS levels were decreased, in comparison to the diabetic group. In addition, Borago significantly increased blood testosterone levels, compared to the diabetic group. Conclusion: The present study showed that, Borago officinalis in male mice has a healing effect on sperm parameters against the damage of diabeteshttp://sjku.muk.ac.ir/article-1-8161-en.pdfdiabetstreptozotocinborago officinalis lsperm parameters |
| spellingShingle | Nabaz abasi shiva khalesro Erfan daneshi Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes مجله علمی دانشگاه علوم پزشکی کردستان diabet streptozotocin borago officinalis l sperm parameters |
| title | Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes |
| title_full | Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes |
| title_fullStr | Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes |
| title_full_unstemmed | Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes |
| title_short | Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes |
| title_sort | ameliorative effect of borago officinalis l extract on sperm parameters testosterone level in a streptozotocin induced mouse model of diabetes |
| topic | diabet streptozotocin borago officinalis l sperm parameters |
| url | http://sjku.muk.ac.ir/article-1-8161-en.pdf |
| work_keys_str_mv | AT nabazabasi ameliorativeeffectofboragoofficinalislextractonspermparameterstestosteronelevelinastreptozotocininducedmousemodelofdiabetes AT shivakhalesro ameliorativeeffectofboragoofficinalislextractonspermparameterstestosteronelevelinastreptozotocininducedmousemodelofdiabetes AT erfandaneshi ameliorativeeffectofboragoofficinalislextractonspermparameterstestosteronelevelinastreptozotocininducedmousemodelofdiabetes |