Leukocytes: The Double-Edged Sword in Fibrosis
Skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts. Scaring is strongly associated with inflammation and wound healing to regain tissue integ...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/652035 |
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| _version_ | 1832552882223710208 |
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| author | Jakub Kryczka Joanna Boncela |
| author_facet | Jakub Kryczka Joanna Boncela |
| author_sort | Jakub Kryczka |
| collection | DOAJ |
| description | Skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts. Scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response to skin tissue injury. However, increased and uncontrolled inflammation, repetitive injury, and individual predisposition might lead to fibrosis, a severe disorder resulting in the formation of dense and stiff tissue that loses the physical properties and physiological functions of normal tissue. Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. Herein, we discuss the current knowledge on the multidimensional impact of leukocytes on the induction of fibrosis, focusing on skin fibrosis. |
| format | Article |
| id | doaj-art-d536f2dae9db4fd791385c9dbe3c4cd4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d536f2dae9db4fd791385c9dbe3c4cd42025-02-03T05:57:37ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/652035652035Leukocytes: The Double-Edged Sword in FibrosisJakub Kryczka0Joanna Boncela1Institute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, PolandInstitute of Medical Biology, Polish Academy of Sciences, 93-232 Lodz, PolandSkin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts. Scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response to skin tissue injury. However, increased and uncontrolled inflammation, repetitive injury, and individual predisposition might lead to fibrosis, a severe disorder resulting in the formation of dense and stiff tissue that loses the physical properties and physiological functions of normal tissue. Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. Herein, we discuss the current knowledge on the multidimensional impact of leukocytes on the induction of fibrosis, focusing on skin fibrosis.http://dx.doi.org/10.1155/2015/652035 |
| spellingShingle | Jakub Kryczka Joanna Boncela Leukocytes: The Double-Edged Sword in Fibrosis Mediators of Inflammation |
| title | Leukocytes: The Double-Edged Sword in Fibrosis |
| title_full | Leukocytes: The Double-Edged Sword in Fibrosis |
| title_fullStr | Leukocytes: The Double-Edged Sword in Fibrosis |
| title_full_unstemmed | Leukocytes: The Double-Edged Sword in Fibrosis |
| title_short | Leukocytes: The Double-Edged Sword in Fibrosis |
| title_sort | leukocytes the double edged sword in fibrosis |
| url | http://dx.doi.org/10.1155/2015/652035 |
| work_keys_str_mv | AT jakubkryczka leukocytesthedoubleedgedswordinfibrosis AT joannaboncela leukocytesthedoubleedgedswordinfibrosis |