Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications
Esophageal cancer (EC) presents substantial therapeutic challenges due to its high mortality rate and the tendency for diagnosis at advanced stages. Acknowledging the constraints of the existing current treatment paradigm, there is a pressing need for the development of innovative, targeted therapeu...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1532558/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582916902748160 |
|---|---|
| author | Zhenglin He Yishuo Ji Yutong Yuan Tianfang Liang Chenglin Liu Yiping Jiao Yimeng Chen Yiming Yang Liang Han Liang Han Yue Hu Yue Hu Xianling Cong Xianling Cong Xianling Cong |
| author_facet | Zhenglin He Yishuo Ji Yutong Yuan Tianfang Liang Chenglin Liu Yiping Jiao Yimeng Chen Yiming Yang Liang Han Liang Han Yue Hu Yue Hu Xianling Cong Xianling Cong Xianling Cong |
| author_sort | Zhenglin He |
| collection | DOAJ |
| description | Esophageal cancer (EC) presents substantial therapeutic challenges due to its high mortality rate and the tendency for diagnosis at advanced stages. Acknowledging the constraints of the existing current treatment paradigm, there is a pressing need for the development of innovative, targeted therapeutic strategies to surpass the current stagnation in survival rate improvements. Recently, microRNAs (miRNAs) have attracted significant attention for their capacity to regulate gene expression at the post-transcriptional level, thereby influencing various cellular processes. In this review, we provide a comprehensive analysis of the role of miRNAs in EC, emphasizing their mechanisms in tumorigenesis, their potential as diagnostic and prognostic biomarkers, and their influence on resistance to therapy. We elucidate how miRNAs modulate oncogenic pathways and tumor suppressor genes, influencing EC cell behavior and treatment outcomes. By integrating insights from genetic sequencing and molecular biology, we identify key miRNAs that promote or inhibit EC progression and treatment resistance. This review highlights critical need for an enhanced understanding of miRNAs in EC, advocating for their integration into therapeutic strategies. |
| format | Article |
| id | doaj-art-d52655d9bafb47f699dd43d89f447148 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-d52655d9bafb47f699dd43d89f4471482025-01-29T06:45:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.15325581532558Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applicationsZhenglin He0Yishuo Ji1Yutong Yuan2Tianfang Liang3Chenglin Liu4Yiping Jiao5Yimeng Chen6Yiming Yang7Liang Han8Liang Han9Yue Hu10Yue Hu11Xianling Cong12Xianling Cong13Xianling Cong14China-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaThe First Bethune Hospital of Jilin University, Jilin University, Changchun, ChinaThe First Bethune Hospital of Jilin University, Jilin University, Changchun, ChinaThe Second Bethune Hospital of Jilin University, Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Cell Biology, College of Basic Medical Science, Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Pathology, China-Japan Union Hospital of Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Jilin University, Changchun, ChinaDepartment of Biobank, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, ChinaEsophageal cancer (EC) presents substantial therapeutic challenges due to its high mortality rate and the tendency for diagnosis at advanced stages. Acknowledging the constraints of the existing current treatment paradigm, there is a pressing need for the development of innovative, targeted therapeutic strategies to surpass the current stagnation in survival rate improvements. Recently, microRNAs (miRNAs) have attracted significant attention for their capacity to regulate gene expression at the post-transcriptional level, thereby influencing various cellular processes. In this review, we provide a comprehensive analysis of the role of miRNAs in EC, emphasizing their mechanisms in tumorigenesis, their potential as diagnostic and prognostic biomarkers, and their influence on resistance to therapy. We elucidate how miRNAs modulate oncogenic pathways and tumor suppressor genes, influencing EC cell behavior and treatment outcomes. By integrating insights from genetic sequencing and molecular biology, we identify key miRNAs that promote or inhibit EC progression and treatment resistance. This review highlights critical need for an enhanced understanding of miRNAs in EC, advocating for their integration into therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fphar.2025.1532558/fullmicroRNAsesophageal cancerpathogenesisdiagnosisprognosistreatment resistance |
| spellingShingle | Zhenglin He Yishuo Ji Yutong Yuan Tianfang Liang Chenglin Liu Yiping Jiao Yimeng Chen Yiming Yang Liang Han Liang Han Yue Hu Yue Hu Xianling Cong Xianling Cong Xianling Cong Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications Frontiers in Pharmacology microRNAs esophageal cancer pathogenesis diagnosis prognosis treatment resistance |
| title | Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications |
| title_full | Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications |
| title_fullStr | Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications |
| title_full_unstemmed | Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications |
| title_short | Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications |
| title_sort | uncovering the role of micrornas in esophageal cancer from pathogenesis to clinical applications |
| topic | microRNAs esophageal cancer pathogenesis diagnosis prognosis treatment resistance |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1532558/full |
| work_keys_str_mv | AT zhenglinhe uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yishuoji uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yutongyuan uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT tianfangliang uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT chenglinliu uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yipingjiao uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yimengchen uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yimingyang uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT lianghan uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT lianghan uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yuehu uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT yuehu uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT xianlingcong uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT xianlingcong uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications AT xianlingcong uncoveringtheroleofmicrornasinesophagealcancerfrompathogenesistoclinicalapplications |