BV/ODV-E26 is a conserved baculoviral inhibitory factor for optimizing viral virulence in lepidopteran hosts
Summary: Alphabaculoviruses induce abnormal behavior in lepidopteran larval hosts. A baculoviral gene, bv/odv-e26, is crucial for behavioral manipulation in Bombyx mori larvae by Bombyx mori nucleopolyhedrovirus (BmNPV). However, how bv/odv-e26 fulfills its role in this phenotype remains largely unk...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422402950X |
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| Summary: | Summary: Alphabaculoviruses induce abnormal behavior in lepidopteran larval hosts. A baculoviral gene, bv/odv-e26, is crucial for behavioral manipulation in Bombyx mori larvae by Bombyx mori nucleopolyhedrovirus (BmNPV). However, how bv/odv-e26 fulfills its role in this phenotype remains largely unknown. In this study, we found that the overexpression of BmNPV bv/odv-e26 delayed viral infection in cultured cells and decreased pathogenicity in B. mori larvae. We also discovered that homologs of bv/odv-e26 are conserved more widely in alphabaculoviruses than previously thought. The inhibitory activity was demonstrated in bv/odv-e26 homologs of phylogenetically close and distant baculoviruses, indicating conserved inhibitory function among alphabaculoviruses. Furthermore, locomotory analyses revealed that bv/odv-e26 increased larval locomotory activity but had little effect on the timing of abnormal behavior initiation. Collectively, our findings demonstrate that bv/odv-e26 is a baculoviral inhibitory factor that is widely conserved in the genus alphabaculovirus and may reduce viral virulence for successful host behavioral manipulation. |
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| ISSN: | 2589-0042 |