Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation
Background. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2020/3679585 |
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| author | Erhan Aysan Fikrettin Sahin Ruzgar Catal Mirkhaliq Javadov Alev Cumbul |
| author_facet | Erhan Aysan Fikrettin Sahin Ruzgar Catal Mirkhaliq Javadov Alev Cumbul |
| author_sort | Erhan Aysan |
| collection | DOAJ |
| description | Background. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically. Results. Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p<0.001). Conclusion. 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism. |
| format | Article |
| id | doaj-art-d506019ce488496cb4a9cfe3c2e84544 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-d506019ce488496cb4a9cfe3c2e845442025-02-03T06:46:08ZengWileyObstetrics and Gynecology International1687-95891687-95972020-01-01202010.1155/2020/36795853679585Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion FormationErhan Aysan0Fikrettin Sahin1Ruzgar Catal2Mirkhaliq Javadov3Alev Cumbul4Yeditepe University, Faculty of Medicine, Department of General Surgery, Istanbul, TurkeyYeditepe University, Faculty of Engineering, Department of Genetic and Bioengineering, Istanbul, TurkeyYeditepe University, Medical School Student, Istanbul, TurkeyYeditepe University, Faculty of Medicine, Department of General Surgery, Istanbul, TurkeyYeditepe University, Department of Histology and Embriology, Istanbul, TurkeyBackground. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically. Results. Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p<0.001). Conclusion. 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.http://dx.doi.org/10.1155/2020/3679585 |
| spellingShingle | Erhan Aysan Fikrettin Sahin Ruzgar Catal Mirkhaliq Javadov Alev Cumbul Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation Obstetrics and Gynecology International |
| title | Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation |
| title_full | Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation |
| title_fullStr | Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation |
| title_full_unstemmed | Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation |
| title_short | Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation |
| title_sort | effects of glycerol and sodium pentaborate formulation on prevention of postoperative peritoneal adhesion formation |
| url | http://dx.doi.org/10.1155/2020/3679585 |
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