Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo

Significance of FXa and its receptor PAR2 for the growth of colon cancer cells in vitro and in vivo

Colon cancer is among the most common cancer types worldwide. Signaling pathways that control cell proliferation and migration play a crucial role in its progression. The G-protein-coupled protease-activated receptors (PARs) are associated mediators in this process. Both activated coagulation factor...

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Bibliographic Details
Main Authors: Ulrike Meyer, Vincent Rönnpagel, Sophie Grammbauer, Mirjam von Lucadou, Ursula Rauch-Kröhnert, Edzard Schwedhelm, Frank Dombrowski, Christoph Ritter, Bernhard H. Rauch
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
mouse model
colon cancer
PAR2 in colon cancer
FXa in colon cancer
in vivo study
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1631350/full
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