Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide
A series of N-nitro acid amide derivatives compounds were synthesized based on the active site of target acetohydroxyacid synthase (AHAS, EC: 2.2.1.6) enzyme. All the structures of newly prepared compounds were thoroughly characterized by satisfied IR and 1H NMR spectra. The IC50 values against AHAS...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/8583765 |
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| author | Xiaojuan Qi Wenjie Tang Shan Gao Min Gao Changshui Chen Qingye Zhang |
| author_facet | Xiaojuan Qi Wenjie Tang Shan Gao Min Gao Changshui Chen Qingye Zhang |
| author_sort | Xiaojuan Qi |
| collection | DOAJ |
| description | A series of N-nitro acid amide derivatives compounds were synthesized based on the active site of target acetohydroxyacid synthase (AHAS, EC: 2.2.1.6) enzyme. All the structures of newly prepared compounds were thoroughly characterized by satisfied IR and 1H NMR spectra. The IC50 values against AHAS enzyme and EC50 values for herbicidal activity against Amaranthus mangostanus L. and Sorghum sudanense of all synthesized target compounds were determined. The compounds II-10, II-21, and II-22 with IC50 values of 7.09 mg/L, 9.07 mg/L, and 9.11 mg/L and the compounds II-8 and II-22 with EC50 values of 9.87 mg/L and 19.88 mg/L against root of Amaranthus mangostanus L. and Sorghum sudanense were illustrated, respectively. Meanwhile, the possible reasons for the lower activity of compounds were analyzed by molecular docking prediction. |
| format | Article |
| id | doaj-art-d4c20f3ecfd0400882dcb3ae0be9c0f4 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-d4c20f3ecfd0400882dcb3ae0be9c0f42025-02-03T01:31:37ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/85837658583765Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of HerbicideXiaojuan Qi0Wenjie Tang1Shan Gao2Min Gao3Changshui Chen4Qingye Zhang5College of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaA series of N-nitro acid amide derivatives compounds were synthesized based on the active site of target acetohydroxyacid synthase (AHAS, EC: 2.2.1.6) enzyme. All the structures of newly prepared compounds were thoroughly characterized by satisfied IR and 1H NMR spectra. The IC50 values against AHAS enzyme and EC50 values for herbicidal activity against Amaranthus mangostanus L. and Sorghum sudanense of all synthesized target compounds were determined. The compounds II-10, II-21, and II-22 with IC50 values of 7.09 mg/L, 9.07 mg/L, and 9.11 mg/L and the compounds II-8 and II-22 with EC50 values of 9.87 mg/L and 19.88 mg/L against root of Amaranthus mangostanus L. and Sorghum sudanense were illustrated, respectively. Meanwhile, the possible reasons for the lower activity of compounds were analyzed by molecular docking prediction.http://dx.doi.org/10.1155/2016/8583765 |
| spellingShingle | Xiaojuan Qi Wenjie Tang Shan Gao Min Gao Changshui Chen Qingye Zhang Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide Journal of Chemistry |
| title | Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide |
| title_full | Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide |
| title_fullStr | Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide |
| title_full_unstemmed | Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide |
| title_short | Design Synthesis and Biological Evaluation of Novel N-Nitro Acid Amide Derivatives as Lead Compounds of Herbicide |
| title_sort | design synthesis and biological evaluation of novel n nitro acid amide derivatives as lead compounds of herbicide |
| url | http://dx.doi.org/10.1155/2016/8583765 |
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