The complexities of elexacaftor/tezacaftor/ivacaftor therapeutic drug monitoring in a person with cystic fibrosis and Mycobacterium abscessus pulmonary disease

The complexities of elexacaftor/tezacaftor/ivacaftor therapeutic drug monitoring in a person with cystic fibrosis and Mycobacterium abscessus pulmonary disease

Therapeutic drug monitoring (TDM) of elexacaftor/tezacaftor/ivacaftor (ETI) remains challenging due to a lack of clarity around the parameters that govern ETI plasma concentrations, whilst the use of concomitant CYP3A inducers rifabutin and rifampicin is not recommended. We present the complexities...

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Bibliographic Details
Main Authors: Claire Y Mou, Daniel J Henderson, Angela G Matson, Karen M Herd, David W Reid, Timothy Riddles, Ellie Johnson, Brett McWhinney, Rebecca Swenson, Andrew Burke, Ieuan E S Evans
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:European Clinical Respiratory Journal
Subjects:
Therapeutic drug monitoring
Cystic Fibrosis
Trikafta
Kaftrio
non-tuberculous mycobacteria
elexacaftor/tezacaftor/ivacaftor
Online Access:https://www.tandfonline.com/doi/10.1080/20018525.2025.2458341
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