A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment
Abstract With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, the heterogeneity, drug resistance, and poor prognosis o...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06077-2 |
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| author | Aoling Huang Haochen Xue Ting Xie Lingyan Xiang Zhengzhuo Chen Aolong Ma Honglin Yan Jingping Yuan |
| author_facet | Aoling Huang Haochen Xue Ting Xie Lingyan Xiang Zhengzhuo Chen Aolong Ma Honglin Yan Jingping Yuan |
| author_sort | Aoling Huang |
| collection | DOAJ |
| description | Abstract With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms. Mitochondria, highly dynamic intracellular organelles, play a pivotal role in maintaining cellular energy metabolism. Altered mitochondrial function plays a critical role in various diseases, and recent studies have elucidated its pathophysiological mechanisms in breast carcinogenesis. This review explores the role of mitochondrial dysfunction in breast cancer pathogenesis and assesses potential mitochondria-targeted therapies. |
| format | Article |
| id | doaj-art-d4830cdf75ed4097a47e365d90fac350 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-d4830cdf75ed4097a47e365d90fac3502025-01-19T12:37:22ZengBMCJournal of Translational Medicine1479-58762025-01-0123111410.1186/s12967-025-06077-2A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatmentAoling Huang0Haochen Xue1Ting Xie2Lingyan Xiang3Zhengzhuo Chen4Aolong Ma5Honglin Yan6Jingping Yuan7Department of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityDepartment of Pathology, Renmin Hospital of Wuhan UniversityAbstract With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms. Mitochondria, highly dynamic intracellular organelles, play a pivotal role in maintaining cellular energy metabolism. Altered mitochondrial function plays a critical role in various diseases, and recent studies have elucidated its pathophysiological mechanisms in breast carcinogenesis. This review explores the role of mitochondrial dysfunction in breast cancer pathogenesis and assesses potential mitochondria-targeted therapies.https://doi.org/10.1186/s12967-025-06077-2MitochondriaMitochondrial dynamicsBreast cancerMitochondrial metabolismApoptosis |
| spellingShingle | Aoling Huang Haochen Xue Ting Xie Lingyan Xiang Zhengzhuo Chen Aolong Ma Honglin Yan Jingping Yuan A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment Journal of Translational Medicine Mitochondria Mitochondrial dynamics Breast cancer Mitochondrial metabolism Apoptosis |
| title | A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment |
| title_full | A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment |
| title_fullStr | A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment |
| title_full_unstemmed | A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment |
| title_short | A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment |
| title_sort | review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment |
| topic | Mitochondria Mitochondrial dynamics Breast cancer Mitochondrial metabolism Apoptosis |
| url | https://doi.org/10.1186/s12967-025-06077-2 |
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