A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies

A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part one: The principles of glucose clamp studies

Glucose clamp studies are used to determine pharmacokinetics (PK) and pharmacodynamics (PD) of analogue insulins. With the development of longer-acting basal analogue insulins, including glargine 300 (Gla-300) and insulin degludec (IDeg), results from numerous glucose clamp studies are readily avail...

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Bibliographic Details
Main Authors: Oppel B.W. Greeff, Jacob John van Tonder, Kershlin Naidu, Alicia McMaster, Alet van Tonder, Rashem Mothilal
Format: Article
Language:English
Published: AOSIS 2018-07-01
Series:South African Family Practice
Subjects:
analogue insulins
glucose clamp
time–action profile
glucose infusion rate
pharmacokinetics
Online Access:https://safpj.co.za/index.php/safpj/article/view/4874
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