Considering best practice standards for routine whole-genome sequencing for TB care and control
TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information suppo...
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| Format: | Article |
| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-10-01
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| Series: | IJTLD Open |
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| author | J.T. Denholm G. de Vries R. Anthony E. Robinson M. Backx I.F. Laurenson A.L. Seagar H. Modestil L. Trieu J.S. Meissner D.H.L. Ng J.Y. Tay H.H. Lin R. Lee V. Sintchenko B.J. Marais E.J. Donnan |
| author_facet | J.T. Denholm G. de Vries R. Anthony E. Robinson M. Backx I.F. Laurenson A.L. Seagar H. Modestil L. Trieu J.S. Meissner D.H.L. Ng J.Y. Tay H.H. Lin R. Lee V. Sintchenko B.J. Marais E.J. Donnan |
| author_sort | J.T. Denholm |
| collection | DOAJ |
| description | TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information supports a variety of aspects of the public health response, including the detection of drug resistance, monitoring of laboratory and clinical practices, contact tracing investigations and active case finding. Optimal structures and approaches are needed to support the rapid translation of genomic information into practice and to evaluate outcomes and impact. In this consensus paper, we outline the elements needed to systemically incorporate routine WGS into the TB public health response, including the sustainability of services, multidisciplinary team models and monitoring and evaluation frameworks. If integrated in an efficient and thoughtful manner, routine WGS has the potential to significantly improve clinical TB care for individuals and the overall public health response. |
| format | Article |
| id | doaj-art-d47555f170f94fb1a041474823fbc8d2 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-d47555f170f94fb1a041474823fbc8d22025-01-23T13:28:38ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-10-0111043143610.5588/ijtldopen.24.03202Considering best practice standards for routine whole-genome sequencing for TB care and controlJ.T. Denholm0G. de Vries1R. Anthony2E. Robinson3M. Backx4I.F. Laurenson5A.L. Seagar6H. Modestil7L. Trieu8J.S. Meissner9D.H.L. Ng10J.Y. Tay11H.H. Lin12R. Lee13V. Sintchenko14B.J. Marais15E.J. Donnan16Victorian Tuberculosis Program, Melbourne, VIC, Australia;Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;TB Unit and National Mycobacterial Reference Service, United Kingdom Health Security Agency, London, UK;Department of Microbiology, University Hospital of Wales, Cardiff, UK;Scottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK;Scottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK;New York City Department of Health and Mental Hygiene, New York, NY, USA;New York City Department of Health and Mental Hygiene, New York, NY, USA;New York City Department of Health and Mental Hygiene, New York, NY, USA;National Tuberculosis Programme, National Centre for Infectious Diseases, Singapore;National Tuberculosis Programme, National Centre for Infectious Diseases, Singapore;Institute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taiwan;Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada;NSW Mycobacterium Reference Laboratory, Institute of Clinical Pathology and Medical Research, NSW Health, Sydney, NSW, Australia;Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia;Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia;TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The increasing availability of real-time genomic information supports a variety of aspects of the public health response, including the detection of drug resistance, monitoring of laboratory and clinical practices, contact tracing investigations and active case finding. Optimal structures and approaches are needed to support the rapid translation of genomic information into practice and to evaluate outcomes and impact. In this consensus paper, we outline the elements needed to systemically incorporate routine WGS into the TB public health response, including the sustainability of services, multidisciplinary team models and monitoring and evaluation frameworks. If integrated in an efficient and thoughtful manner, routine WGS has the potential to significantly improve clinical TB care for individuals and the overall public health response.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000010/art00002mycobacterium tuberculosistuberculosisgenomicspublic healthcomputational biologycluster analysispolicy making |
| spellingShingle | J.T. Denholm G. de Vries R. Anthony E. Robinson M. Backx I.F. Laurenson A.L. Seagar H. Modestil L. Trieu J.S. Meissner D.H.L. Ng J.Y. Tay H.H. Lin R. Lee V. Sintchenko B.J. Marais E.J. Donnan Considering best practice standards for routine whole-genome sequencing for TB care and control IJTLD Open mycobacterium tuberculosis tuberculosis genomics public health computational biology cluster analysis policy making |
| title | Considering best practice standards for routine whole-genome sequencing for TB care and control |
| title_full | Considering best practice standards for routine whole-genome sequencing for TB care and control |
| title_fullStr | Considering best practice standards for routine whole-genome sequencing for TB care and control |
| title_full_unstemmed | Considering best practice standards for routine whole-genome sequencing for TB care and control |
| title_short | Considering best practice standards for routine whole-genome sequencing for TB care and control |
| title_sort | considering best practice standards for routine whole genome sequencing for tb care and control |
| topic | mycobacterium tuberculosis tuberculosis genomics public health computational biology cluster analysis policy making |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000010/art00002 |
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