A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China
Purpose. The present study investigated the prevalence of keratoconus (KC) among first-degree relatives of KC patients in Central China. Methods. From July 2018 to March 2022, 661 first-degree relatives of 384 KC patients were included in the present study. Corneal tomography, uncorrected distance v...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/6609531 |
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| author | Yawen Wang Liyan Xu Shaopei Wang Kaili Yang Yuwei Gu Qi Fan Qing Wang Meng Zhu Kai Guo Chenjiu Pang Shengwei Ren Dongqing Zhao |
| author_facet | Yawen Wang Liyan Xu Shaopei Wang Kaili Yang Yuwei Gu Qi Fan Qing Wang Meng Zhu Kai Guo Chenjiu Pang Shengwei Ren Dongqing Zhao |
| author_sort | Yawen Wang |
| collection | DOAJ |
| description | Purpose. The present study investigated the prevalence of keratoconus (KC) among first-degree relatives of KC patients in Central China. Methods. From July 2018 to March 2022, 661 first-degree relatives of 384 KC patients were included in the present study. Corneal tomography, uncorrected distance visual acuity, manifest refraction with corrected distance visual acuity, intraocular pressure, slit-lamp microscopy, and fundus examination were performed. The diagnosis of KC was based on the Belin/Ambrosio enhanced ectasia total deviation value (BAD-D value) on the Pentacam® system (Oculus GmbH). BAD-D value <1.6 was diagnosed as healthy, 1.6≤ BAD-D value <2.6 was diagnosed as suspected KC, and BAD-D value ≥2.6 was diagnosed as KC. Results. The present study included 337 (50.98%) female and 324 (49.02%) male subjects. The prevalence of KC and suspected KC in first-degree relatives was 8.77% (n = 58) and 29.05% (n = 192), respectively. The prevalence of KC was 9.70% among parents and 7.23% among siblings. Conclusions. The higher prevalence of KC among first-degree relatives of patients with KC suggests that first-degree relatives of KC are at high risk of developing KC. |
| format | Article |
| id | doaj-art-d470ebc42f614baf9ad8c46834249424 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-d470ebc42f614baf9ad8c468342494242025-02-03T05:53:35ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/6609531A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central ChinaYawen Wang0Liyan Xu1Shaopei Wang2Kaili Yang3Yuwei Gu4Qi Fan5Qing Wang6Meng Zhu7Kai Guo8Chenjiu Pang9Shengwei Ren10Dongqing Zhao11Henan University People’s HospitalHenan Provincial People’s HospitalXinxiang Medical UniversityHenan Provincial People’s HospitalHenan Provincial People’s HospitalHenan Provincial People’s HospitalHenan University People’s HospitalZhengzhou University People’s HospitalZhengzhou University People’s HospitalHenan Provincial People’s HospitalHenan University People’s HospitalHenan University People’s HospitalPurpose. The present study investigated the prevalence of keratoconus (KC) among first-degree relatives of KC patients in Central China. Methods. From July 2018 to March 2022, 661 first-degree relatives of 384 KC patients were included in the present study. Corneal tomography, uncorrected distance visual acuity, manifest refraction with corrected distance visual acuity, intraocular pressure, slit-lamp microscopy, and fundus examination were performed. The diagnosis of KC was based on the Belin/Ambrosio enhanced ectasia total deviation value (BAD-D value) on the Pentacam® system (Oculus GmbH). BAD-D value <1.6 was diagnosed as healthy, 1.6≤ BAD-D value <2.6 was diagnosed as suspected KC, and BAD-D value ≥2.6 was diagnosed as KC. Results. The present study included 337 (50.98%) female and 324 (49.02%) male subjects. The prevalence of KC and suspected KC in first-degree relatives was 8.77% (n = 58) and 29.05% (n = 192), respectively. The prevalence of KC was 9.70% among parents and 7.23% among siblings. Conclusions. The higher prevalence of KC among first-degree relatives of patients with KC suggests that first-degree relatives of KC are at high risk of developing KC.http://dx.doi.org/10.1155/2022/6609531 |
| spellingShingle | Yawen Wang Liyan Xu Shaopei Wang Kaili Yang Yuwei Gu Qi Fan Qing Wang Meng Zhu Kai Guo Chenjiu Pang Shengwei Ren Dongqing Zhao A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China Journal of Ophthalmology |
| title | A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China |
| title_full | A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China |
| title_fullStr | A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China |
| title_full_unstemmed | A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China |
| title_short | A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China |
| title_sort | hospital based study on the prevalence of keratoconus in first degree relatives of patients with keratoconus in central china |
| url | http://dx.doi.org/10.1155/2022/6609531 |
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