Cytotoxic Effect of Benzofuranoid Neolignans from Myristica fragrans Seeds Against Melanoma B16-F10 Cancer Cells
Myristica fragrans is an indigenous plant in Indonesia, characterized by various secondary metabolites with diverse bioactivities. This plant possesses promising anti-melanoma properties capable of addressing prevalent cases of melanoma. Therefore, this study’s objective was to isolate potential co...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ITB Journal Publisher
2024-12-01
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| Series: | Journal of Mathematical and Fundamental Sciences |
| Subjects: | |
| Online Access: | http://167.205.195.146/ojsnew/index.php/jmfs/article/view/23358 |
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| Summary: | Myristica fragrans is an indigenous plant in Indonesia, characterized by various secondary metabolites with diverse bioactivities. This plant possesses promising anti-melanoma properties capable of addressing prevalent cases of melanoma. Therefore, this study’s objective was to isolate potential compounds from Myristica fragrans seeds and assess their cytotoxic effects on melanoma B16-F10 cells. Ethyl acetate extracts were subjected to separation through various chromatographic methods to obtain three benzofuranoid neolignans, which was conducted using spectroscopic analyses, namely UV-vis, polarimeter, HRTOF-MS, IR, and NMR. Subsequently, comparison with previously reported spectral data confirmed the identities of neolignans as (+)-licarin A (1), (+)-licarin B (2), and (+)-maceneolignan B (3). Cytotoxicity against melanoma B16-F10 cells was assessed using the PrestoBlue method, revealing (+)-licarin A (1) to display the most potent activity with an IC50 value of 94.15 μM.
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| ISSN: | 2337-5760 2338-5510 |