Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies
Abstract Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor samples, super enhancers have been identif...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06098-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585456266510336 |
|---|---|
| author | Yumeng Ji Baixue Li Rongjin Lin Jing Yuan Yang Han Yuping Du Yang Zhao |
| author_facet | Yumeng Ji Baixue Li Rongjin Lin Jing Yuan Yang Han Yuping Du Yang Zhao |
| author_sort | Yumeng Ji |
| collection | DOAJ |
| description | Abstract Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor samples, super enhancers have been identified as crucial players in the development and progression of tumor cells, opening up new avenues for cancer research and treatment. This review provides a concise overview of various models regarding super enhancer assembly and activation, examining the mechanisms through which tumor cells acquire or activate these enhancers and regulate carcinogenic transcription programs. Furthermore, we discuss the current landscape and challenges in developing cancer therapeutic drugs that target super enhancers. |
| format | Article |
| id | doaj-art-d463aef5ab3d4f01a791e0f892b61285 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-d463aef5ab3d4f01a791e0f892b612852025-01-26T12:50:13ZengBMCJournal of Translational Medicine1479-58762025-01-0123111710.1186/s12967-025-06098-xSuper-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapiesYumeng Ji0Baixue Li1Rongjin Lin2Jing Yuan3Yang Han4Yuping Du5Yang Zhao6Department of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Department of Gynecologic Oncology Research Office, Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical UniversityAbstract Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby regulating cellular activities. In tumor samples, super enhancers have been identified as crucial players in the development and progression of tumor cells, opening up new avenues for cancer research and treatment. This review provides a concise overview of various models regarding super enhancer assembly and activation, examining the mechanisms through which tumor cells acquire or activate these enhancers and regulate carcinogenic transcription programs. Furthermore, we discuss the current landscape and challenges in developing cancer therapeutic drugs that target super enhancers.https://doi.org/10.1186/s12967-025-06098-xSuper enhancerTranscription regulatoryCancerTargeted therapy |
| spellingShingle | Yumeng Ji Baixue Li Rongjin Lin Jing Yuan Yang Han Yuping Du Yang Zhao Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies Journal of Translational Medicine Super enhancer Transcription regulatory Cancer Targeted therapy |
| title | Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies |
| title_full | Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies |
| title_fullStr | Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies |
| title_full_unstemmed | Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies |
| title_short | Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies |
| title_sort | super enhancers in tumors unraveling recent advances in their role in oncogenesis and the emergence of targeted therapies |
| topic | Super enhancer Transcription regulatory Cancer Targeted therapy |
| url | https://doi.org/10.1186/s12967-025-06098-x |
| work_keys_str_mv | AT yumengji superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies AT baixueli superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies AT rongjinlin superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies AT jingyuan superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies AT yanghan superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies AT yupingdu superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies AT yangzhao superenhancersintumorsunravelingrecentadvancesintheirroleinoncogenesisandtheemergenceoftargetedtherapies |