Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications
Ischemic stroke caused by arterial occlusion is the most common type of stroke and is one of the leading causes of disability and death, with the incidence increasing each year. Fyn is a nonreceptor tyrosine kinase belonging to the Src family of kinases (SFKs), which is related to many normal and pa...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/9112127 |
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| author | Fang Du Tao Tang Qingzhu Li Jiaxin Liu |
| author_facet | Fang Du Tao Tang Qingzhu Li Jiaxin Liu |
| author_sort | Fang Du |
| collection | DOAJ |
| description | Ischemic stroke caused by arterial occlusion is the most common type of stroke and is one of the leading causes of disability and death, with the incidence increasing each year. Fyn is a nonreceptor tyrosine kinase belonging to the Src family of kinases (SFKs), which is related to many normal and pathological processes of the nervous system, including neurodevelopment and disease progression. In recent years, more and more evidence suggests that Fyn may be closely related to cerebral ischemia-reperfusion, including energy metabolism disorders, excitatory neurotoxicity, intracellular calcium homeostasis, free radical production, and the activation of apoptotic genes. This paper reviews the role of Fyn in the pathological process of cerebral ischemia-reperfusion, including neuroexcitotoxicity and neuroinflammation, to explore how Fyn affects specific signal cascades and leads to cerebral ischemia-reperfusion injury. In addition, Fyn also promotes the production of superoxide and endogenous NO, so as to quickly react to produce peroxynitrite, which may also mediate cerebral ischemia-reperfusion injury, which is discussed in this paper. Finally, we revealed the treatment methods related to Fyn inhibitors and discussed its potential as a clinical treatment for ischemic stroke. |
| format | Article |
| id | doaj-art-d45985fcf3fc4bfd9eec69b7d366436b |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d45985fcf3fc4bfd9eec69b7d366436b2025-02-03T06:00:56ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/9112127Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic ImplicationsFang Du0Tao Tang1Qingzhu Li2Jiaxin Liu3Medical School of Kunming University of Science and TechnologyMedical School of Kunming University of Science and TechnologyYan’an Hospital of KunmingMedical School of Kunming University of Science and TechnologyIschemic stroke caused by arterial occlusion is the most common type of stroke and is one of the leading causes of disability and death, with the incidence increasing each year. Fyn is a nonreceptor tyrosine kinase belonging to the Src family of kinases (SFKs), which is related to many normal and pathological processes of the nervous system, including neurodevelopment and disease progression. In recent years, more and more evidence suggests that Fyn may be closely related to cerebral ischemia-reperfusion, including energy metabolism disorders, excitatory neurotoxicity, intracellular calcium homeostasis, free radical production, and the activation of apoptotic genes. This paper reviews the role of Fyn in the pathological process of cerebral ischemia-reperfusion, including neuroexcitotoxicity and neuroinflammation, to explore how Fyn affects specific signal cascades and leads to cerebral ischemia-reperfusion injury. In addition, Fyn also promotes the production of superoxide and endogenous NO, so as to quickly react to produce peroxynitrite, which may also mediate cerebral ischemia-reperfusion injury, which is discussed in this paper. Finally, we revealed the treatment methods related to Fyn inhibitors and discussed its potential as a clinical treatment for ischemic stroke.http://dx.doi.org/10.1155/2022/9112127 |
| spellingShingle | Fang Du Tao Tang Qingzhu Li Jiaxin Liu Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications Mediators of Inflammation |
| title | Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications |
| title_full | Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications |
| title_fullStr | Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications |
| title_full_unstemmed | Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications |
| title_short | Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications |
| title_sort | fyn signaling in ischemia reperfusion injury potential and therapeutic implications |
| url | http://dx.doi.org/10.1155/2022/9112127 |
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