Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma
Background and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/5970852 |
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| author | Leonardo do Prado Lima Carla Jorge Machado João Bernardo Sancio Rocha Rodrigues Leonardo de Souza Vasconcellos Eduardo Paulino Junior Paula Vieira Teixeira Vidigal Vivian Resende |
| author_facet | Leonardo do Prado Lima Carla Jorge Machado João Bernardo Sancio Rocha Rodrigues Leonardo de Souza Vasconcellos Eduardo Paulino Junior Paula Vieira Teixeira Vidigal Vivian Resende |
| author_sort | Leonardo do Prado Lima |
| collection | DOAJ |
| description | Background and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. Methods. This study included Child-Pugh A HCC patients undergoing curative surgical resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. EpCAM+ expression was associated with AFP + (OR = 12.5, 95% CI, 1.9-84.1, p<0.001). In univariate analysis, a significant association was observed between AFP+ and EPCAM+ and the serum AFP level. A diameter of ≤ 5 cm was associated with EPCAM+, while angiolymphatic invasion was associated with APF+. In a multivariate analysis, only tumors of ≤ 5 cm were significantly associated with EpCAM+ (OR = 8.7; 95%CI, 1.27-100.0; p = 0.022). The overall survival rate was 74.9%, 69.4%, 69.4%, and 53.5% at 12, 24, 36, and 48 months, respectively. Conclusion. A considerable number of patients with EpCAM+ HCC would benefit from a specific target therapy. |
| format | Article |
| id | doaj-art-d450d2e70b0940549b113fbc9770f7ee |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-d450d2e70b0940549b113fbc9770f7ee2025-02-03T01:11:33ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/59708525970852Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular CarcinomaLeonardo do Prado Lima0Carla Jorge Machado1João Bernardo Sancio Rocha Rodrigues2Leonardo de Souza Vasconcellos3Eduardo Paulino Junior4Paula Vieira Teixeira Vidigal5Vivian Resende6Departamento de Cirurgia, Hospital das Clínicas da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilDepartamento de Medicina Social e Preventiva da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilDepartamento de Cirurgia, Hospital das Clínicas da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilDepartamento de Patologia Clínica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilDepartamento de Histopatologia da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilDepartamento de Histopatologia da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilDepartamento de Cirurgia, Hospital das Clínicas da Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilBackground and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. Methods. This study included Child-Pugh A HCC patients undergoing curative surgical resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. EpCAM+ expression was associated with AFP + (OR = 12.5, 95% CI, 1.9-84.1, p<0.001). In univariate analysis, a significant association was observed between AFP+ and EPCAM+ and the serum AFP level. A diameter of ≤ 5 cm was associated with EPCAM+, while angiolymphatic invasion was associated with APF+. In a multivariate analysis, only tumors of ≤ 5 cm were significantly associated with EpCAM+ (OR = 8.7; 95%CI, 1.27-100.0; p = 0.022). The overall survival rate was 74.9%, 69.4%, 69.4%, and 53.5% at 12, 24, 36, and 48 months, respectively. Conclusion. A considerable number of patients with EpCAM+ HCC would benefit from a specific target therapy.http://dx.doi.org/10.1155/2018/5970852 |
| spellingShingle | Leonardo do Prado Lima Carla Jorge Machado João Bernardo Sancio Rocha Rodrigues Leonardo de Souza Vasconcellos Eduardo Paulino Junior Paula Vieira Teixeira Vidigal Vivian Resende Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma Canadian Journal of Gastroenterology and Hepatology |
| title | Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma |
| title_full | Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma |
| title_fullStr | Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma |
| title_full_unstemmed | Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma |
| title_short | Immunohistochemical Coexpression of Epithelial Cell Adhesion Molecule and Alpha-Fetoprotein in Hepatocellular Carcinoma |
| title_sort | immunohistochemical coexpression of epithelial cell adhesion molecule and alpha fetoprotein in hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2018/5970852 |
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