Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women
Background. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. Previously, we reported that hsCRP indu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/516783 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555959237476352 |
|---|---|
| author | Nicole Noren Hooten Ngozi Ejiogu Alan B. Zonderman Michele K. Evans |
| author_facet | Nicole Noren Hooten Ngozi Ejiogu Alan B. Zonderman Michele K. Evans |
| author_sort | Nicole Noren Hooten |
| collection | DOAJ |
| description | Background. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. Previously, we reported that hsCRP induces the oxidative stress adduct 8-oxo-7,8-dihydro-2′deoxyguanosine (8-oxodG) and that these markers are significantly associated in women. Recent data indicates that brain-derived neurotrophic factor (BDNF) may have a role in CVD. Methods and Results. We examined BDNF levels in 3 groups of women that were age- and race-matched with low (<3 mg/L), mid (>3–20 mg/L), and high (>20 mg/L) hsCRP (n=39 per group) and found a significant association between hsCRP, BDNF, and 8-oxodG. In African American females with high hsCRP, increases in BDNF were associated with decreased serum 8-oxodG. This was not the case in white women where high hsCRP was associated with high levels of BDNF and high levels of 8-oxodG. BDNF treatment of cells reduced CRP levels and inhibited CRP-induced DNA damage. Conclusion. We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels >3 mg/L. These data suggest that BDNF may have a protective role in counteracting the inflammatory effects of hsCRP. |
| format | Article |
| id | doaj-art-d440a6a25c10460f8d606c18669f979c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d440a6a25c10460f8d606c18669f979c2025-02-03T05:46:45ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/516783516783Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in WomenNicole Noren Hooten0Ngozi Ejiogu1Alan B. Zonderman2Michele K. Evans3Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USALaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USABackground. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. Previously, we reported that hsCRP induces the oxidative stress adduct 8-oxo-7,8-dihydro-2′deoxyguanosine (8-oxodG) and that these markers are significantly associated in women. Recent data indicates that brain-derived neurotrophic factor (BDNF) may have a role in CVD. Methods and Results. We examined BDNF levels in 3 groups of women that were age- and race-matched with low (<3 mg/L), mid (>3–20 mg/L), and high (>20 mg/L) hsCRP (n=39 per group) and found a significant association between hsCRP, BDNF, and 8-oxodG. In African American females with high hsCRP, increases in BDNF were associated with decreased serum 8-oxodG. This was not the case in white women where high hsCRP was associated with high levels of BDNF and high levels of 8-oxodG. BDNF treatment of cells reduced CRP levels and inhibited CRP-induced DNA damage. Conclusion. We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels >3 mg/L. These data suggest that BDNF may have a protective role in counteracting the inflammatory effects of hsCRP.http://dx.doi.org/10.1155/2015/516783 |
| spellingShingle | Nicole Noren Hooten Ngozi Ejiogu Alan B. Zonderman Michele K. Evans Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women Mediators of Inflammation |
| title | Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women |
| title_full | Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women |
| title_fullStr | Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women |
| title_full_unstemmed | Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women |
| title_short | Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women |
| title_sort | protective effects of bdnf against c reactive protein induced inflammation in women |
| url | http://dx.doi.org/10.1155/2015/516783 |
| work_keys_str_mv | AT nicolenorenhooten protectiveeffectsofbdnfagainstcreactiveproteininducedinflammationinwomen AT ngoziejiogu protectiveeffectsofbdnfagainstcreactiveproteininducedinflammationinwomen AT alanbzonderman protectiveeffectsofbdnfagainstcreactiveproteininducedinflammationinwomen AT michelekevans protectiveeffectsofbdnfagainstcreactiveproteininducedinflammationinwomen |