Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions
Background: Huntington’s disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions. Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/15/1/10 |
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| author | Ali Yilmaz Sumeyya Akyol Nadia Ashrafi Nazia Saiyed Onur Turkoglu Stewart F. Graham |
| author_facet | Ali Yilmaz Sumeyya Akyol Nadia Ashrafi Nazia Saiyed Onur Turkoglu Stewart F. Graham |
| author_sort | Ali Yilmaz |
| collection | DOAJ |
| description | Background: Huntington’s disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions. Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in the huntingtin gene (HTT) as a critical factor. The development of innovative strategies is imperative for the early detection of predictive biomarkers, enabling timely intervention and mitigating irreversible cellular damage. Lipidomics, a comprehensive analytical approach, has emerged as an indispensable tool for systematically characterizing lipid profiles and elucidating their role in disease pathology. Method: A MedLine search was performed to identify studies that use lipidomics for the characterization of HD. Search terms included “Huntington disease”; “lipidomics”; “biomarker discovery”; “NMR”; and “Mass spectrometry”. Results: This review highlights the significance of lipidomics in HD diagnosis and treatment, exploring changes in brain lipids and their functions. Recent breakthroughs in analytical techniques, particularly mass spectrometry and NMR spectroscopy, have revolutionized brain lipidomics research, enabling researchers to gain deeper insights into the complex lipidome of the brain. Conclusions: A comprehensive understanding of the broad spectrum of lipidomics alterations in HD is vital for precise diagnostic evaluation and effective disease management. The integration of lipidomics with artificial intelligence and interdisciplinary collaboration holds promise for addressing the clinical variability of HD. |
| format | Article |
| id | doaj-art-d43bda0f22024d9695e7f20bc0ed4b00 |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-d43bda0f22024d9695e7f20bc0ed4b002025-01-24T13:41:09ZengMDPI AGMetabolites2218-19892025-01-011511010.3390/metabo15010010Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future DirectionsAli Yilmaz0Sumeyya Akyol1Nadia Ashrafi2Nazia Saiyed3Onur Turkoglu4Stewart F. Graham5Department of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Rochester, MI 48309, USANX Prenatal Inc., 4350 Brownsboro Rd, Louisville, KY 40207, USADepartment of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Rochester, MI 48309, USAMetabolomics Division, Beaumont Research Institute, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USADepartment of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Rochester, MI 48309, USADepartment of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Rochester, MI 48309, USABackground: Huntington’s disease (HD) is a multifaceted neurological disorder characterized by the progressive deterioration of motor, cognitive, and psychiatric functions. Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in the huntingtin gene (HTT) as a critical factor. The development of innovative strategies is imperative for the early detection of predictive biomarkers, enabling timely intervention and mitigating irreversible cellular damage. Lipidomics, a comprehensive analytical approach, has emerged as an indispensable tool for systematically characterizing lipid profiles and elucidating their role in disease pathology. Method: A MedLine search was performed to identify studies that use lipidomics for the characterization of HD. Search terms included “Huntington disease”; “lipidomics”; “biomarker discovery”; “NMR”; and “Mass spectrometry”. Results: This review highlights the significance of lipidomics in HD diagnosis and treatment, exploring changes in brain lipids and their functions. Recent breakthroughs in analytical techniques, particularly mass spectrometry and NMR spectroscopy, have revolutionized brain lipidomics research, enabling researchers to gain deeper insights into the complex lipidome of the brain. Conclusions: A comprehensive understanding of the broad spectrum of lipidomics alterations in HD is vital for precise diagnostic evaluation and effective disease management. The integration of lipidomics with artificial intelligence and interdisciplinary collaboration holds promise for addressing the clinical variability of HD.https://www.mdpi.com/2218-1989/15/1/10Huntington’s diseaselipidomicsbiomarker discoveryNMRmass spectrometry |
| spellingShingle | Ali Yilmaz Sumeyya Akyol Nadia Ashrafi Nazia Saiyed Onur Turkoglu Stewart F. Graham Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions Metabolites Huntington’s disease lipidomics biomarker discovery NMR mass spectrometry |
| title | Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions |
| title_full | Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions |
| title_fullStr | Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions |
| title_full_unstemmed | Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions |
| title_short | Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions |
| title_sort | lipidomics of huntington s disease a comprehensive review of current status and future directions |
| topic | Huntington’s disease lipidomics biomarker discovery NMR mass spectrometry |
| url | https://www.mdpi.com/2218-1989/15/1/10 |
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