Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations
Adult-onset Still’s disease is an inflammatory multisystemic disease of unknown etiology. Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils. We report a case of an eosinophilic pleural effusion as a novel and hitherto u...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/981232 |
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| _version_ | 1832565063267909632 |
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| author | Katerina M. Antoniou George A. Margaritopoulos Ioannis Giannarakis Christianna Choulaki Nikos Fountoulakis Nikos M. Siafakas Prodromos Sidiropoulos |
| author_facet | Katerina M. Antoniou George A. Margaritopoulos Ioannis Giannarakis Christianna Choulaki Nikos Fountoulakis Nikos M. Siafakas Prodromos Sidiropoulos |
| author_sort | Katerina M. Antoniou |
| collection | DOAJ |
| description | Adult-onset Still’s disease is an inflammatory multisystemic disease of unknown etiology. Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils. We report a case of an eosinophilic pleural effusion as a novel and hitherto unrecognized manifestation of active adult-onset Still’s disease. We also observed a marked NLRP3 inflammasome activation with increased production of IL-1β which coincided with the development and resolved upon remission of the pleural effusion suggesting a possible novel pathogenetic pathway for the development of pleural effusions in the context of the auto-inflammatory disorders. |
| format | Article |
| id | doaj-art-d42b14adfdf04673bd6a41684d45bb43 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-d42b14adfdf04673bd6a41684d45bb432025-02-03T01:09:38ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/981232981232Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological CorrelationsKaterina M. Antoniou0George A. Margaritopoulos1Ioannis Giannarakis2Christianna Choulaki3Nikos Fountoulakis4Nikos M. Siafakas5Prodromos Sidiropoulos6Interstitial Lung Disease Unit, Thoracic Medicine Department, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceInterstitial Lung Disease Unit, Thoracic Medicine Department, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceInterstitial Lung Disease Unit, Thoracic Medicine Department, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceDepartment of Rheumatology, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceDepartment of Rheumatology, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceInterstitial Lung Disease Unit, Thoracic Medicine Department, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceDepartment of Rheumatology, University Hospital of Heraklion, 71110 Heraklion, Crete, GreeceAdult-onset Still’s disease is an inflammatory multisystemic disease of unknown etiology. Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils. We report a case of an eosinophilic pleural effusion as a novel and hitherto unrecognized manifestation of active adult-onset Still’s disease. We also observed a marked NLRP3 inflammasome activation with increased production of IL-1β which coincided with the development and resolved upon remission of the pleural effusion suggesting a possible novel pathogenetic pathway for the development of pleural effusions in the context of the auto-inflammatory disorders.http://dx.doi.org/10.1155/2013/981232 |
| spellingShingle | Katerina M. Antoniou George A. Margaritopoulos Ioannis Giannarakis Christianna Choulaki Nikos Fountoulakis Nikos M. Siafakas Prodromos Sidiropoulos Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations Case Reports in Medicine |
| title | Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations |
| title_full | Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations |
| title_fullStr | Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations |
| title_full_unstemmed | Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations |
| title_short | Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations |
| title_sort | adult onset still s disease a case report with a rare clinical manifestation and pathophysiological correlations |
| url | http://dx.doi.org/10.1155/2013/981232 |
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